国际儿科结核病的最新进展。

Updates in Pediatric Tuberculosis in International Settings.

机构信息

Department of Pathology, Section of Microbiology, Aga Khan University, Supariwala Building, PO Box 3500, Karachi, Pakistan.

Department of Pediatrics and Child Health, The Aga Khan University, Faculty Office Building, PO Box 3500, Stadium Road, Karachi 74800, Pakistan.

出版信息

Pediatr Clin North Am. 2022 Feb;69(1):19-45. doi: 10.1016/j.pcl.2021.09.004.

DOI:10.1016/j.pcl.2021.09.004

PMID:34794675

Abstract

Childhood tuberculosis (TB) has been underreported and underrepresented in TB statistics across the globe. Contributing factors include health system barriers, diagnostic barriers, and community barriers leading to an underdetected epidemic of childhood tuberculosis. Despite considerable progress in childhood TB management, there is a concerning gap in policy and practice in high-burden countries leading to missed opportunities for active case detection, early diagnosis and treatment of TB exposure, and infection and disease in children regardless of human immunodeficiency virus status. Bridging this gap requires multisectoral coordination and political commitment along with an eye to research and innovation with potential to scale.

摘要

全球范围内，儿童结核病（TB）的报告和代表性不足。造成这种情况的因素包括卫生系统障碍、诊断障碍和社区障碍，导致儿童结核病的漏检率很高。尽管在儿童结核病管理方面取得了相当大的进展，但在高负担国家的政策和实践方面仍存在差距，导致错失了主动发现病例、早期诊断和治疗 TB 暴露以及感染和发病的机会，而无论其人类免疫缺陷病毒状态如何。缩小这一差距需要多部门协调和政治承诺，同时关注有潜力扩大规模的研究和创新。