Suppr超能文献

儿童结核病管理:全球挑战还是突破?

Pediatric Tuberculosis Management: A Global Challenge or Breakthrough?

作者信息

Maphalle Lehlogonolo N F, Michniak-Kohn Bozena B, Ogunrombi Modupe O, Adeleke Oluwatoyin A

机构信息

Division of Pharmaceutical Sciences, School of Pharmacy, Sefako Makgatho Health Sciences University, Pretoria 0208, South Africa.

Ernest Mario School of Pharmacy, Rutgers-The State University of New Jersey, 160 Frelinghuysen Road, Piscataway, NJ 08854, USA.

出版信息

Children (Basel). 2022 Jul 27;9(8):1120. doi: 10.3390/children9081120.

Abstract

Managing pediatric tuberculosis (TB) remains a public health problem requiring urgent and long-lasting solutions as TB is one of the top ten causes of ill health and death in children as well as adolescents universally. Minors are particularly susceptible to this severe illness that can be fatal post-infection or even serve as reservoirs for future disease outbreaks. However, pediatric TB is the least prioritized in most health programs and optimal infection/disease control has been quite neglected for this specialized patient category, as most scientific and clinical research efforts focus on developing novel management strategies for adults. Moreover, the ongoing coronavirus pandemic has meaningfully hindered the gains and progress achieved with TB prophylaxis, therapy, diagnosis, and global eradication goals for all affected persons of varying age bands. Thus, the opening of novel research activities and opportunities that can provide more insight and create new knowledge specifically geared towards managing TB disease in this specialized group will significantly improve their well-being and longevity.

摘要

由于结核病是全球儿童和青少年健康不良及死亡的十大原因之一,因此,应对儿童结核病仍然是一个需要紧急和长期解决方案的公共卫生问题。未成年人尤其容易感染这种严重疾病,感染后可能致命,甚至可能成为未来疾病爆发的源头。然而,在大多数卫生项目中,儿童结核病的优先级最低,针对这一特殊患者群体的最佳感染/疾病控制措施一直被忽视,因为大多数科学和临床研究工作都集中在为成年人开发新的治疗策略上。此外,持续的新冠疫情严重阻碍了在结核病预防、治疗、诊断以及所有不同年龄段受影响人群的全球根除目标方面所取得的成果和进展。因此,开展新的研究活动和创造机会,以提供更多见解并创造专门针对管理这一特殊群体结核病的新知识,将显著改善他们的健康状况并延长寿命。

引用本文的文献

1
Nanotechnological innovations in paediatric tuberculosis management: current trends and future prospects.
Front Drug Deliv. 2024 Jan 8;3:1295815. doi: 10.3389/fddev.2023.1295815. eCollection 2023.
2
Imaging of post-tuberculosis lung disease cases in children and adolescent survivors: a systematic review.
Eur Clin Respir J. 2025 Aug 18;12(1):2547515. doi: 10.1080/20018525.2025.2547515. eCollection 2025.
3
Caregiver perspectives on TB-related stigma experienced by young children.
IJTLD Open. 2025 Aug 13;2(8):443-449. doi: 10.5588/ijtldopen.25.0293. eCollection 2025 Aug.
6
Comparison of chest ultrasound features to chest radiography in the diagnosis for pediatric tuberculosis: a cross-sectional study.
Pan Afr Med J. 2024 Nov 27;49:95. doi: 10.11604/pamj.2024.49.95.45265. eCollection 2024.
7
A critical perspective on paediatric pulmonary tuberculosis and diagnostic advancements.
Afr J Thorac Crit Care Med. 2024 Dec 11;30(4):e2883. doi: 10.7196/AJTCCM.2024.v30i4.2883. eCollection 2024.
10
Temporal pattern and effect of COVID-19 on the trend of TB, DRTB, paediatrics TB and TB with HIV Coinfection: A decadal trend analysis.
J Family Med Prim Care. 2024 Dec;13(12):5555-5561. doi: 10.4103/jfmpc.jfmpc_466_24. Epub 2024 Dec 9.

本文引用的文献

1
Pediatric Tuberculosis Research and Development: Progress, Priorities and Funding Opportunities.
Pathogens. 2022 Jan 21;11(2):128. doi: 10.3390/pathogens11020128.
2
Pediatric TB detection in the era of COVID-19.
Indian J Tuberc. 2022 Jan;69(1):104-108. doi: 10.1016/j.ijtb.2021.04.015. Epub 2021 May 6.
3
Outcomes of SARS-CoV-2-Positive Youths Tested in Emergency Departments: The Global PERN-COVID-19 Study.
JAMA Netw Open. 2022 Jan 4;5(1):e2142322. doi: 10.1001/jamanetworkopen.2021.42322.
4
Diagnostic accuracy of Truenat Tuberculosis and Rifampicin-Resistance assays in Addis Ababa, Ethiopia.
PLoS One. 2021 Dec 28;16(12):e0261084. doi: 10.1371/journal.pone.0261084. eCollection 2021.
5
Evaluation of the BNT162b2 Covid-19 Vaccine in Children 5 to 11 Years of Age.
N Engl J Med. 2022 Jan 6;386(1):35-46. doi: 10.1056/NEJMoa2116298. Epub 2021 Nov 9.
8
The Differential Diagnosis of Sterile Pyuria in Pediatric Patients: A Review.
Glob Pediatr Health. 2021 May 6;8:2333794X21993712. doi: 10.1177/2333794X21993712. eCollection 2021.
9
Four-Month Rifapentine Regimens with or without Moxifloxacin for Tuberculosis.
N Engl J Med. 2021 May 6;384(18):1705-1718. doi: 10.1056/NEJMoa2033400.
10
Discovery and Validation of a Three-Cytokine Plasma Signature as a Biomarker for Diagnosis of Pediatric Tuberculosis.
Front Immunol. 2021 Apr 16;12:653898. doi: 10.3389/fimmu.2021.653898. eCollection 2021.

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验