回旋加速器生产的放射性金属中过渡金属杂质的测定方法

Methods for the Determination of Transition Metal Impurities in Cyclotron-Produced Radiometals.

作者信息

Forgács Viktória, Fekete Anikó, Gyuricza Barbara, Szücs Dániel, Trencsényi György, Szikra Dezső

机构信息

Department of Medical Imaging, Division of Nuclear Medicine and Translational Imaging, Faculty of Medicine, University of Debrecen, Nagyerdei krt. 98., H-4032 Debrecen, Hungary.

Faculty of Science and Technology, Doctoral School of Chemistry, University of Debrecen, Egyetem tér 1, H-4032 Debrecen, Hungary.

出版信息

Pharmaceuticals (Basel). 2022 Jan 26;15(2):147. doi: 10.3390/ph15020147.

DOI:10.3390/ph15020147

PMID:35215260

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8880423/

Abstract

Cyclotron-produced radiometals must be separated from the irradiated target and purified from other metal impurities, which could interfere with the radiolabeling process. We compared different chromatographic and colorimetric methods to determine the amount of transition metals in radioactive samples. Besides commercially available colorimetric tests, 4-(2-pyridylazo)resorcinol and xylenol orange were used as a non-selective metal reagents, forming water-soluble chelates with most of the transition metals immediately. We compared the applicability of pre- and post-column derivatization, as well as colorimetric determination without separation. The studied chromatographic and colorimetric analyses are not suitable to completely replace atomic spectroscopic techniques for the determination of metal contaminants in radioactive samples, but they may play an important role in the development of methods for the purification of radiometals and in their routine quality control.

摘要

回旋加速器产生的放射性金属必须与被辐照的靶材分离，并从其他可能干扰放射性标记过程的金属杂质中纯化出来。我们比较了不同的色谱法和比色法，以测定放射性样品中过渡金属的含量。除了市售的比色测试外，4-（2-吡啶偶氮）间苯二酚和二甲酚橙被用作非选择性金属试剂，可立即与大多数过渡金属形成水溶性螯合物。我们比较了柱前衍生和柱后衍生的适用性，以及不进行分离的比色测定。所研究的色谱分析和比色分析并不适合完全替代原子光谱技术来测定放射性样品中的金属污染物，但它们可能在放射性金属纯化方法的开发及其常规质量控制中发挥重要作用。