Department of Medical Physics and Radiology, University of Wisconsin-Madison B1303 WIMR Cyclotron Laboratory, 1111 Highland Avenue, Madison WI 53705, United States.
Cyclotrons and Tracer center GE Health care, Uppsala, Sweden.
Curr Radiopharm. 2021;14(4):315-324. doi: 10.2174/1874471013666201224113651.
Gallium-68 is a positron-emitting nuclide that has recently achieved clinical acceptance as the diagnostic radionuclide in PET tracers used for theranostic studies of lutetium-177 labeled therapeutic drugs due to the ease of access provided by germanium-68/gallium-68 generators. An alternative method of production currently being explored uses accelerators to form gallium-68 directly. This review of gallium-68 production strategies discusses available accelerator targetry at a range of beam energies and intensities, the many radiochemical separation techniques available to isolate Ga-68 from irradiated targets, isotopically enriched target material recovery, and the implications of these techniques for downstream radiolabeling applications.
镓-68 是一种正电子发射核素，由于锗-68/镓-68 发生器提供的便捷获取途径，最近已在用于镥-177 标记治疗药物的治疗性研究的 PET 示踪剂中作为诊断放射性核素获得临床认可。目前正在探索的另一种生产方法是使用加速器直接形成镓-68。本文综述了镓-68 的生产策略，讨论了在一系列束流能量和强度下可用的加速器靶材，以及可用于从辐照靶中分离 Ga-68 的多种放射化学分离技术、同位素富集靶材料的回收，以及这些技术对下游放射性标记应用的影响。
