The Department of Surgery, Division of Plastic and Reconstructive Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Int J Mol Sci. 2022 Feb 15;23(4):2127. doi: 10.3390/ijms23042127.
The lymphatic system consists of a unidirectional hierarchy of vessels responsible for fluid homeostasis, lipid absorption, and the transport of immune cells and antigens to secondary lymphoid organs. In cancer, lymphatics play complex and heterogenous roles that can promote or inhibit tumor growth. While lymphatic proliferation and remodeling promote tumor dissemination, functional lymphatics are necessary for generating an effective immune response. Recent reports have noted lymphatic-dependent effects on the efficacy of immunotherapy. These findings suggest that the impact of lymphatic vessels on tumor progression is organ- and context-specific and that a greater understanding of the interaction of tumor cells, lymphatics, and the tumor microenvironment can unveil novel therapies.
淋巴系统由负责液体平衡、脂质吸收以及免疫细胞和抗原向次级淋巴器官运输的单向层次结构组成。在癌症中，淋巴管发挥着复杂和异质的作用，可以促进或抑制肿瘤生长。虽然淋巴管的增殖和重塑促进了肿瘤的扩散，但功能性淋巴管对于产生有效的免疫反应是必要的。最近的报告指出了淋巴管对免疫疗法疗效的影响。这些发现表明，淋巴管对肿瘤进展的影响具有器官和背景特异性，并且对肿瘤细胞、淋巴管和肿瘤微环境相互作用的更深入理解可以揭示新的治疗方法。
