Bunney W E
Am J Psychiatry. 1978 Jul;135 Suppl:8-13.
There have been major advances in the treatment of psychoses in the past decade, particularly in the area of maintenance therapy with lithium, tricyclics, and neuroleptics. Such efforts have been enhanced by methods of relating plasma drug levels to clinical efficacy. Research in genetic factors, the mode of action of pharmacological agents, and hormonal influences on psychopathology has added to our theoretical understanding of the psychoses, and we can hope for further advances from sophisticated new methodological tools. Promising areas of investigation include the search for genetic markers, studies of postsynaptic neuronal receptors, and examination of the effects of polypeptides, including endogenous opioid compounds.
在过去十年里，精神病治疗取得了重大进展，尤其是在锂盐、三环类药物和抗精神病药物的维持治疗领域。将血浆药物水平与临床疗效相关联的方法进一步推动了这些进展。对遗传因素、药物作用模式以及激素对精神病理学影响的研究，加深了我们对精神病的理论理解，并且我们有望借助先进的新方法工具取得进一步进展。有前景的研究领域包括寻找遗传标记、研究突触后神经元受体以及检测多肽（包括内源性阿片类化合物）的作用。
