酸性肿瘤微环境：调控免疫反应以引发逃逸
The acidic tumour microenvironment: Manipulating the immune response to elicit escape.
作者信息
Worsley Catherine M, Veale Rob B, Mayne Elizabeth S
机构信息
Department of Immunology, Faculty of Health Sciences, University of Pretoria, South Africa; Department of Haematology and Molecular Medicine, Faculty of Health Sciences, University of the Witwatersrand, South Africa; National Health Laboratory Service, South Africa.
School of Molecular and Cell Biology, Faculty of Science, University of the Witwatersrand, South Africa.
出版信息
Hum Immunol. 2022 May;83(5):399-408. doi: 10.1016/j.humimm.2022.01.014. Epub 2022 Feb 22.
The success of cancer treatment relies on the composition of the tumour microenvironment which is comprised of tumour cells, blood vessels, stromal cells, immune cells, and extracellular matrix components. Barriers to effective cancer treatment need to be overcome, and the acidic microenvironment of the tumour provides a key target for treatment. This review intends to provide an overview of the effects that low extracellular pH has on components of the tumour microenvironment and how they contribute to immune escape. Further, potential therapeutic targets will be discussed.
癌症治疗的成功依赖于肿瘤微环境的组成，肿瘤微环境由肿瘤细胞、血管、基质细胞、免疫细胞和细胞外基质成分组成。有效癌症治疗的障碍需要被克服，而肿瘤的酸性微环境提供了一个关键的治疗靶点。本综述旨在概述细胞外低pH值对肿瘤微环境成分的影响以及它们如何导致免疫逃逸。此外，还将讨论潜在的治疗靶点。
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