Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China; Liangzhu Laboratory, Zhejiang University Medical Center, Hangzhou 311121, China.
J Control Release. 2022 Apr;344:272-288. doi: 10.1016/j.jconrel.2022.02.023. Epub 2022 Feb 22.
The dynamic roles of T cells in the immune system to recognize and destroy the infected or mutated cells render T cell therapy a prospective treatment for a variety of diseases including cancer, autoimmune diseases, and allograft rejection. However, the clinical applications of T cell therapy remain unsatisfactory due to the tedious manufacturing process, off-target cytotoxicity, poor cell persistence, and associated adverse effects. To this end, various biomaterials have been introduced to enhance T cell therapy by facilitating proliferation, enhancing local enrichment, prolonging retention, and alleviating side effects. This review highlights the design strategies of biomaterials developed for T cell expansion, enrichment, and delivery as well as their corresponding therapeutic effects. The prospects of biomaterials for enhancing T cell immunotherapy are also discussed in this review.
T 细胞在免疫系统中识别和摧毁受感染或突变细胞的动态作用，使 T 细胞疗法成为治疗包括癌症、自身免疫性疾病和同种异体移植排斥在内的多种疾病的有前途的方法。然而，由于繁琐的制造工艺、脱靶细胞毒性、细胞持久性差以及相关的不良反应，T 细胞疗法的临床应用仍不尽如人意。为此，各种生物材料被引入以通过促进增殖、增强局部富集、延长保留时间和减轻副作用来增强 T 细胞疗法。本综述强调了为 T 细胞扩增、富集和递送来开发的生物材料的设计策略及其相应的治疗效果。本文还讨论了生物材料在增强 T 细胞免疫疗法中的前景。
