Orthopedic Center, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524000, Guangdong Province, China.
Department of Orthopedics and Traumatology, Prince of Wales Hospital, Faculty of Medicine, The Chinese University of Hong Kong, Hongkong 999077, China.
Zhejiang Da Xue Xue Bao Yi Xue Ban. 2024 Aug 25;53(4):450-459. doi: 10.3724/zdxbyxb-2023-0619.
Bone remodeling and bone regeneration are essential for preserving skeletal integrity and maintaining mineral homeostasis. T cells, as key members of adaptive immunity, play a pivotal role in bone remodeling and bone regeneration by producing a range of cytokines and growth factors. In the physiological state, T cells are involved in the maintenance of bone homeostasis through interactions with mesenchymal stem cells, osteoblasts, and osteoclasts. In pathological states, T cells participate in the pathological process of different types of osteoporosis through interaction with estrogen, glucocorticoids, and parathyroid hormone. During fracture healing for post-injury repair, T cells play different roles during the inflammatory hematoma phase, the bone callus formation phase and the bone remodeling phase. Targeting T cells thus emerges as a potential strategy for regulating bone homeostasis. This article reviews the research progress on related mechanisms of T cells immunity involved in bone remodeling and bone regeneration, with a view to providing a scientific basis for targeting T cells to regulate bone remodeling and bone regeneration.
骨重建和骨再生对于维持骨骼完整性和维持矿物质内稳态至关重要。T 细胞作为适应性免疫系统的关键成员，通过产生一系列细胞因子和生长因子，在骨重建和骨再生中发挥关键作用。在生理状态下，T 细胞通过与间充质干细胞、成骨细胞和破骨细胞相互作用，参与维持骨内稳态。在病理状态下，T 细胞通过与雌激素、糖皮质激素和甲状旁腺激素相互作用，参与不同类型骨质疏松症的病理过程。在创伤后修复的骨折愈合过程中，T 细胞在炎症血肿期、骨痂形成期和骨改建期发挥不同的作用。因此，靶向 T 细胞成为调节骨内稳态的一种潜在策略。本文综述了 T 细胞免疫在骨重建和骨再生中相关机制的研究进展，以期为靶向 T 细胞调节骨重建和骨再生提供科学依据。
