Beijing Advanced Innovation Center for Big Data-Based Precision Medicine, Interdisciplinary Innovation Institute of Medicine and Engineering, Beihang University, Beijing, 100191, People's Republic of China.
School of Engineering Medicine, Beihang University, 37 Xueyuan Road, Haidian District, Beijing, 100191, People's Republic of China.
Curr Microbiol. 2022 Feb 26;79(4):117. doi: 10.1007/s00284-022-02812-w.
Acinetobacter baumannii is a common pathogen in hospitals and usually causes bacteremia, pneumonia, meningitis, peritonitis and other diseases. Isolates carried NDM-1 gene can make several antibiotics such as carbapenems and other beta-lactams ineffective. Nowadays, the number of A. baumannii strains carrying NDM-1 has been climbing year by year in recent years. To characterise the transmission of NDM-1 in A. baumannii, we collected 2576 human-derived genomes of A. baumannii strains from NCBI database and found that 186 strains contained NDM-1 gene. The multi-locus sequence typing, phylogenetic tree, NDM-1 gene organization and the single nucleotide polymorphisms of NDM-1 were investigated. We hope that our work will provide a theoretical basis for the prevention of dissemination of NDM-1 in A. baumannii.
鲍曼不动杆菌是医院中的常见病原体，通常会引起菌血症、肺炎、脑膜炎、腹膜炎等疾病。携带 NDM-1 基因的分离株可使碳青霉烯类和其他β-内酰胺类抗生素失效。近年来，携带 NDM-1 的鲍曼不动杆菌菌株数量逐年攀升。为了研究 NDM-1 在鲍曼不动杆菌中的传播情况，我们从 NCBI 数据库中收集了 2576 株人源来源的鲍曼不动杆菌基因组，发现其中 186 株含有 NDM-1 基因。我们对多位点序列分型、系统发育树、NDM-1 基因结构和 NDM-1 的单核苷酸多态性进行了研究。我们希望我们的工作能为预防 NDM-1 在鲍曼不动杆菌中的传播提供理论依据。
