Laboratory of Molecular Microbiology, Institute of Biomedical Sciences, Federal University of Uberlândia, Uberlândia, Brazil.
Hospital das Clínicas and Federal University of Uberlândia, Uberlândia, Brazil.
Microb Drug Resist. 2021 Apr;27(4):471-475. doi: 10.1089/mdr.2020.0219. Epub 2020 Sep 11.
This study used whole-genome sequencing to analyze the first case of NDM-1-producing belonging to the novel sequence type 1465/CC216 recovered in Brazil. The study identified an unusual plasmid carrying gene, in which some genes of the Tn transposon were lost. Besides, on the chromosome, the strain reported here presented gene, a variant of gene, and with IS upstream. The isolation of new STs of carrying genes elicits our concerns about the possible spread of these genes among clinically relevant bacteria.
本研究采用全基因组测序分析了在巴西发现的首例产 NDM-1 的 ，属于新型序列类型 1465/CC216。研究发现了一个携带 基因的不寻常质粒，其中 Tn 转座子的一些基因丢失。此外，在染色体上，该报告菌株呈现出 基因、 基因的变体以及上游带有 IS 的 。携带 基因的新 ST 的分离引起了我们对这些基因在临床相关细菌中传播的可能性的关注。
