Department of Radiology, Hull University Teaching Hospitals NHS Trust, London, UK.
Cancer Research Group, Hull York Medical School, University of Hull, Cottingham, UK.
Ann Nucl Med. 2022 Apr;36(4):329-339. doi: 10.1007/s12149-022-01730-y. Epub 2022 Feb 26.
F-Sodium fluoride (F-NaF) is a PET tracer that is mostly used in the evaluation of bone metastasis in oncology cases. Recently, F-NaF PET/CT is gaining wide popularity owing to its higher sensitivity over the other conventional bone tracer with higher and rapid single-pass extraction, negligible plasma protein binding, rapid blood, and renal clearance. In the era of constant evolution of cancer therapy regimens, considerable bone health impact is seen in the form of avascular necrosis, insufficiency fractures, among others. A significant number of these therapy-induced changes show high bone turnover and thereby F-NaF accumulation, mimicking metastatic lesions. This article summarizes and illustrates the pattern and morphological features of F-NaF PET/CT findings in these changes in the context of clinical and therapeutic history.
氟[18F] 氟化钠（F-NaF）是一种 PET 示踪剂，主要用于肿瘤病例中骨转移的评估。由于其较其他常规骨示踪剂具有更高的灵敏度和更快的单次提取、可忽略不计的血浆蛋白结合、快速的血液和肾脏清除率，F-NaF PET/CT 最近越来越受欢迎。在癌症治疗方案不断发展的时代，以无菌性坏死、疲劳骨折等形式出现了相当多的骨骼健康影响。这些治疗引起的变化中有相当一部分表现出高骨转换，从而导致 F-NaF 积聚，模拟转移病灶。本文总结并说明了在临床和治疗病史的背景下，这些变化中 F-NaF PET/CT 结果的模式和形态特征。
