Fu Jie, Zhang Chi
College of Future Technology, Peking University, Beijing, China.
Department of Orthopedics, Peking University International Hospital, Beijing, China.
Front Pharmacol. 2025 Apr 28;16:1594903. doi: 10.3389/fphar.2025.1594903. eCollection 2025.
Osteoporosis is a common metabolic bone disease that seriously affects the quality of life and health of patients. Traditional diagnostic methods, such as dual energy X-ray absorptiometry (DXA), have limitations in early detection and dynamic monitoring, making it difficult to meet clinical needs. This paper focuses on the potential of radionuclide imaging techniques, such as Single Photon Emission Computed Tomography (SPECT) and Positron Emission Tomography (PET), in the early diagnosis of osteoporosis. The paper further elaborates on the importance of radionuclides in evaluating the therapeutic effect of osteoporosis drugs. By summarizing current research findings, this paper aims to emphasize the core role of radionuclides in the management of osteoporosis, and provide theoretical basis and practical guidance for optimizing the diagnosis and treatment strategies of bone metabolism diseases in the future.
骨质疏松症是一种常见的代谢性骨病，严重影响患者的生活质量和健康。传统的诊断方法，如双能X线吸收法（DXA），在早期检测和动态监测方面存在局限性，难以满足临床需求。本文重点探讨单光子发射计算机断层扫描（SPECT）和正电子发射断层扫描（PET）等放射性核素成像技术在骨质疏松症早期诊断中的潜力。本文还进一步阐述了放射性核素在评估骨质疏松症药物治疗效果方面的重要性。通过总结当前的研究结果，本文旨在强调放射性核素在骨质疏松症管理中的核心作用，并为未来优化骨代谢疾病的诊断和治疗策略提供理论依据和实践指导。
