Division of Biomaterials New York University College of Dentistry 433 1st Avenue, Room 842 New York, NY 10010-4086 USA
Med Oral Patol Oral Cir Bucal. 2022 Mar 1;27(2):e174-e180. doi: 10.4317/medoral.25164.
The aim of the present study was to evaluate the effect of different concentrations of growth hormone (GH) on endosteal implant's surface at the early stages of osseointegration.
Sixty tapered acid-etched titanium implants were divided into four groups: i) Collagen, used as a control group; and three experimental groups, where after collagen coating, GH was administered directly to the surface in varying concentrations: ii) 0.265 mg, iii) 0.53 mg, and iv) 1 mg. Implants were placed in an interpolated fashion in the anterior flange of C3, C4 or C5 of 15 sheep with minimum distance of 6 mm between implants. After 3-, 6- and 12-weeks of healing samples were harvested, histologically processed, qualitatively and quantitatively assessed for bone-to-implant contact (BIC) and bone area fraction occupancy (BAFO).
Statistical analysis as a function of time in vivo and coating resulted in no significant differences for BIC and BAFO at any evaluation time point. Histological evaluation demonstrated similar osseointegration features for all groups with woven bone formation at 3 weeks and progressive replacement of woven for lamellar bone in close contact with the implant surface and within the implant's threads.
A single local application of growth hormone to the surface of titanium implants did not yield improved implant osseointegration independent of healing time.
本研究的目的是评估不同浓度生长激素（GH）对早期骨整合过程中内骨面种植体表面的影响。
将 60 个锥形酸蚀钛种植体分为四组：i）胶原蛋白，作为对照组；和三个实验组，在胶原蛋白涂层后，GH 以不同浓度直接施用于表面：ii）0.265mg，iii）0.53mg，iv）1mg。将种植体以交错方式放置在 15 只绵羊的 C3、C4 或 C5 前翼，相邻种植体之间的最小距离为 6mm。愈合 3、6 和 12 周后，采集样本，进行组织学处理，定性和定量评估骨与种植体接触（BIC）和骨面积占有率（BAFO）。
体内时间和涂层的统计分析在任何评估时间点均未导致 BIC 和 BAFO 出现显著差异。组织学评估显示所有组均具有相似的骨整合特征，在 3 周时形成编织骨，随后编织骨逐渐被与种植体表面紧密接触并位于种植体螺纹内的板层骨替代。
单独将生长激素应用于钛种植体表面并不能改善种植体的骨整合，与愈合时间无关。
