Parra Marcelo, Benalcázar Jalkh Ernesto B, Tovar Nick, Torroni Andrea, Badalov Rafael M, Bonfante Estevam A, Nayak Vasudev, Castellano Arthur, Coelho Paulo G, Witek Lukasz
Int J Oral Maxillofac Implants. 2022 Sep-Oct;37(5):929-936. doi: 10.11607/jomi.9354.
To qualitatively and quantitatively evaluate histologic osseointegration parameters of implants designed with decompressing vertical chambers between the threads with two different surface treatments (TiO blasting + maleic acid vs TiO blasting + maleic + HCl) in a large translational animal model at 3 and 6 weeks in vivo.
Nine female sheep were used, and 72 implants with trapezoidal threads and decompressing vertical chambers of 0.6 mm in diameter and 0.2 mm in depth were placed in the ilium crest. After 3 and 6 weeks, the animals were euthanized, and biomechanical and histomophometric analyses were performed.
Survey histologic evaluation indicated intimate contact between the bone and the implants independent of surface treatment at both times in vivo. Bone formation at both time points depicted an intramembranous-type healing pattern between the implant threads. The mean removal torque values for all groups showed a relative increase in removal torque from 3 to 6 weeks. In terms of bone area fraction occupancy analysis, significant differences were found at 6 weeks between surface treatments (P = .046), where the experimental surface yielded higher degrees of bone area fraction occupancy.
Conical implants with decompressing vertical chambers between threads presented similar osseointegration parameters regarding bone-toimplant contact and torque-out test values irrespective of surface treatment. However, shifting from a minimally rough to a moderately rough surface (experimental surface with supplemental acid-etching) resulted in significantly improved bone area fraction occupancy at 6 weeks.
在一个大型转化动物模型中，对体内3周和6周时采用两种不同表面处理（钛喷砂+马来酸与钛喷砂+马来酸+盐酸）设计的带有螺纹间减压垂直腔的种植体的组织学骨结合参数进行定性和定量评估。
使用9只雌性绵羊，将72枚直径0.6 mm、深度0.2 mm的梯形螺纹和减压垂直腔的种植体植入髂嵴。3周和6周后，对动物实施安乐死，并进行生物力学和组织形态计量学分析。
组织学评估表明，在体内两个时间点，骨与种植体之间均紧密接触，与表面处理无关。两个时间点的骨形成均显示种植体螺纹间为膜内型愈合模式。所有组的平均去除扭矩值显示从3周到6周去除扭矩相对增加。在骨面积分数占有率分析方面，6周时表面处理之间存在显著差异（P = 0.046），其中实验表面的骨面积分数占有率更高。
带有螺纹间减压垂直腔的锥形种植体，无论表面处理如何，在骨与种植体接触及扭矩测试值方面呈现相似的骨结合参数。然而，从微粗糙表面转变为中等粗糙表面（采用补充酸蚀的实验表面）可使6周时的骨面积分数占有率显著提高。
