Department of Biological Sciences, University of Calgary, Calgary, Alberta T2N 1N4, Canada.
Department of Biological Sciences, University of Calgary, Calgary, Alberta T2N 1N4, Canada.
Curr Opin Plant Biol. 2022 Apr;66:102186. doi: 10.1016/j.pbi.2022.102186. Epub 2022 Feb 23.
Plants produce many compounds used by humans as medicines, including alkaloids of the benzylisoquinoline (BIA), monoterpene indole (MIA) and tropane classes. The biosynthetic pathways of these pharmaceutical alkaloids are complex and spatially segregated across several tissues, cell-types and organelles. This review discusses the origin of primary metabolic inputs required by these specialized biosynthetic pathways and considers aspects relevant to their spatial organization. These factors are important for alkaloid production both in the native plants and for synthetic biology pathway reconstruction in microorganisms.
植物产生许多被人类用作药物的化合物，包括苯并异喹啉（BIA）、单萜吲哚（MIA）和托烷类生物碱。这些药用生物碱的生物合成途径复杂，分布在多个组织、细胞类型和细胞器中。本文讨论了这些特殊生物合成途径所需的初级代谢物的来源，并考虑了与其空间组织相关的方面。这些因素对于在原生植物中以及在微生物中进行合成生物学途径重建的生物碱生产都很重要。
