Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynaecology, Erasmus MC, Rotterdam, the Netherlands.
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynaecology, Erasmus MC, Rotterdam, the Netherlands.
Fertil Steril. 2022 May;117(5):1059-1066. doi: 10.1016/j.fertnstert.2022.01.014. Epub 2022 Feb 24.
To assess the effects of aging on the features of polycystic ovary syndrome (PCOS).
Cohort study.
Tertiary care center.
PATIENT(S): Women with PCOS, diagnosed according to the 2003 Rotterdam criteria, who visited our outpatient clinic repeatedly.
INTERVENTION(S): Comparisons were made between the first visit and consecutive visits.
MAIN OUTCOME MEASURE(S): Change in PCOS phenotype groups in terms of clinical and endocrine characteristics.
RESULT(S): A total of 596 women visited the outpatient clinic repeatedly. An estimated change per 5-year age showed a decrease in the prevalence of phenotype A and an increase in the prevalence of not having PCOS. The serum levels of testosterone, androstenedione, and dehydroepiandrosterone sulfate as well as the free androgen index decreased significantly. Clinical characteristics showed an increase in terms of body mass index and waist circumference, whereas plasma glucose levels, insulin levels, and insulin resistance did not change significantly.
CONCLUSION(S): The prevalence of PCOS phenotype groups changes over time. There is an important age effect that indicates a more regular menstrual cycle, decrease in the serum androgen levels, and improvement in polycystic ovarian morphology when aging occurs in women with PCOS.
评估年龄对多囊卵巢综合征（PCOS）特征的影响。
队列研究。
三级保健中心。
多囊卵巢综合征患者，根据 2003 年鹿特丹标准诊断，反复就诊于我院门诊。
比较首次就诊和连续就诊时的情况。
PCOS 表型组在临床和内分泌特征方面的变化。
共 596 名妇女反复就诊于门诊。预计每 5 年年龄变化显示表型 A 的患病率下降，而非多囊卵巢综合征的患病率增加。血清睾酮、雄烯二酮和硫酸脱氢表雄酮以及游离雄激素指数水平显著下降。临床特征方面，体重指数和腰围增加，而血浆葡萄糖水平、胰岛素水平和胰岛素抵抗无明显变化。
PCOS 表型组的患病率随时间而变化。年龄对患有 PCOS 的女性有重要影响，随着年龄的增长，其月经周期更规律，血清雄激素水平降低，多囊卵巢形态改善。
