Ebrahimi Nasim, Adelian Samaneh, Shakerian Siavash, Afshinpour Maral, Chaleshtori Siavash Rahimian, Rostami Nadi, Rezaei-Tazangi Fatemeh, Beiranvand Sheida, Hamblin Michael R, Aref Amir Reza
Division of Genetics, Department of Cell and Molecular & Microbiology, Faculty of Science and Technology, University of Isfahan, Isfahan, Iran.
Cellular and Molecular Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran.
Cytokine Growth Factor Rev. 2022 Apr;64:33-45. doi: 10.1016/j.cytogfr.2022.01.006. Epub 2022 Jan 21.
Both genomic instability and the presence of chronic inflammation are involved in carcinogenesis and tumor progression. These alterations predispose the cancer cells to undergo metabolic reprogramming as well as the epithelial-mesenchymal transition (EMT). These pathways allow cancer cells to avoid apoptosis and stimulate tumor progression. EMT is an important early event in tumor cell invasion, which can be regulated through inflammatory signaling pathways. Cancer cells undergoing EMT are vulnerable to cell death by the process of ferroptosis. Ferroptosis is a form of regulated cell death involving iron-dependent lipid peroxidation, designed to maintain cellular homeostasis. Several reports have linked ferroptosis, inflammation, and cancer. Ferroptosis inhibitors and EMT inducers have been used to understand the anti-inflammatory and anticancer effects in experimental models. A better understanding of the crosstalk between ferroptosis and EMT, and the involvment of inflammatory mediators may accelerate the discovery of therapeutic strategies to eradicate cancer cells and overcome drug-resistance.
基因组不稳定和慢性炎症的存在均与癌症发生及肿瘤进展有关。这些改变使癌细胞易于发生代谢重编程以及上皮-间质转化（EMT）。这些途径使癌细胞能够避免凋亡并促进肿瘤进展。EMT是肿瘤细胞侵袭过程中的一个重要早期事件，其可通过炎症信号通路进行调节。经历EMT的癌细胞在铁死亡过程中易发生细胞死亡。铁死亡是一种涉及铁依赖性脂质过氧化的程序性细胞死亡形式，旨在维持细胞内稳态。多项报告将铁死亡、炎症和癌症联系起来。铁死亡抑制剂和EMT诱导剂已被用于了解实验模型中的抗炎和抗癌作用。更好地理解铁死亡与EMT之间的相互作用以及炎症介质的参与，可能会加速根除癌细胞和克服耐药性的治疗策略的发现。
