Medical Support Center for Japan Environment and Children's Study, National Center for Child Health and Development, Tokyo, Japan.
Medical Support Center for Japan Environment and Children's Study, National Center for Child Health and Development, Tokyo, Japan.
Allergol Int. 2022 Jul;71(3):335-344. doi: 10.1016/j.alit.2022.01.002. Epub 2022 Feb 24.
Allergen-specific immunoglobulins have a crucial role in allergic diseases. Most wheeze episodes develop before school age, and allergic rhinitis later develops during early elementary school years. However, the clinical background and cytokine/chemokine profiles associated with changes in immunoglobulins during early school-age are poorly understood.
This study used blood samples from children participating in the JECS Pilot Study. We examined nineteen kinds of aeroallergen-specific immunoglobulins (IgE, IgG1, IgG4, and IgA) levels in patients at age 6 and age 8. Fluctuations of Der f 1- and Cry j 1-specific immunoglobulins levels during the two periods were compared to assess the frequency of allergic statuses and clusters of cytokine/chemokine profiles.
The medians of aeroallergen-specific IgE levels did not fluctuate, and almost all IgG1 and IgG4 decreased. In IgA, four (e.g., Der f 1) increased, whereas the other four (e.g., Cry j 1) decreased. The ratio of the Der f 1-specific IgG1 level at age 8 to that at age 6 was higher in children with poor asthma control than in children with better asthma control. Moreover, the cytokine/chemokine cluster with relatively lower IL-33 and higher CXCL7/NAP2 was associated with lower Der f 1- and Cry j 1-specific IgG4 levels, but not IgE levels.
The cluster of cytokine/chemokine profiles characterized by lower IL-33 and higher CXCL7/NAP2 was associated with the maintenance of aeroallergen-specific IgG4 levels. This result provides a basis for considering the control of aeroallergen-specific immunoglobulins.
过敏原特异性免疫球蛋白在过敏性疾病中起着至关重要的作用。大多数喘息发作发生在学龄前期，过敏性鼻炎则在小学早期发展。然而，在学龄早期，与免疫球蛋白变化相关的临床背景和细胞因子/趋化因子谱仍知之甚少。
本研究使用了参加 JECS 初步研究的儿童的血液样本。我们在 6 岁和 8 岁时检查了 19 种气传过敏原特异性免疫球蛋白（IgE、IgG1、IgG4 和 IgA）的水平。比较了这两个时期 Der f 1 和 Cry j 1 特异性免疫球蛋白水平的波动，以评估过敏状态的频率和细胞因子/趋化因子谱的聚类。
气传过敏原特异性 IgE 水平的中位数没有波动，几乎所有的 IgG1 和 IgG4 都有所下降。在 IgA 中，有四种（如 Der f 1）增加，而其他四种（如 Cry j 1）减少。与哮喘控制较好的儿童相比，哮喘控制较差的儿童 8 岁时 Der f 1 特异性 IgG1 水平与 6 岁时相比升高。此外，IL-33 水平较低、CXCL7/NAP2 水平较高的细胞因子/趋化因子聚类与较低的 Der f 1 和 Cry j 1 特异性 IgG4 水平相关，但与 IgE 水平无关。
以 IL-33 水平较低、CXCL7/NAP2 水平较高为特征的细胞因子/趋化因子聚类与气传过敏原特异性 IgG4 水平的维持有关。这一结果为考虑控制气传过敏原特异性免疫球蛋白提供了依据。
