Allergy Center, National Center for Child Health and Development, 2-10-1 Okura, Setagaya-Ku, Tokyo, 157-8535, Japan.
Medical Support Center for the Japan Environment and Children's Study, National Research Institute for Child Health and Development, 2-10-1 Okura, Setagaya-Ku, Tokyo, 157-8535, Japan.
BMC Pediatr. 2023 Sep 21;23(1):479. doi: 10.1186/s12887-023-04302-9.
Numerous studies suggest that sex steroids might play a role in sex disparity observed in allergic diseases in adults. However, whether sex hormones influence allergic diseases in children remains unclear. The aim of the present study was to examine the association of sex steroid hormones with allergic disease in Japanese children.
The present cross-sectional study included 145 6-year-old children participating in a pilot birth cohort study in the Japan Environment and Children's Study. Data on allergic diseases were obtained from questionnaires, and serum levels of sex steroid hormones and allergen-specific IgE were measured. Logistic regression was performed to evaluate the association of sex hormones with allergic diseases.
After adjusted sex, amount of body fat at 6 years, parental history of allergic disease, and exposure to tobacco smoke, serum dehydroepiandrosterone sulfate level was significantly associated with reduced odds of any allergic disease (adjusted odds ratio, 0.58; 95% confidence interval, 0.36-0.93; P = 0.024) and serum follicle-stimulating hormone level was significantly associated with increased odds of any allergic disease (adjusted odds ratio, 2.04; 95% confidence interval, 1.01-4.11, P = 0.046). Dehydroepiandrosterone sulfate level showed a significant association with number of allergic diseases.
The current study findings suggest that sex hormones may play an important role in the development of allergic diseases in prepubertal children.
许多研究表明，性激素可能在成年人过敏疾病中的性别差异中发挥作用。然而，性激素是否会影响儿童的过敏疾病尚不清楚。本研究旨在探讨性甾体激素与日本儿童过敏性疾病的关系。
本横断面研究纳入了参加日本环境与儿童研究试点出生队列研究的 145 名 6 岁儿童。通过问卷调查获得过敏疾病数据，并测量血清性激素和过敏原特异性 IgE 水平。采用 logistic 回归评估性激素与过敏性疾病的关系。
在校正性别、6 岁时体脂肪量、父母过敏病史和接触烟草烟雾后，血清脱氢表雄酮硫酸盐水平与任何过敏性疾病的患病风险降低显著相关（校正比值比，0.58；95%置信区间，0.36-0.93；P=0.024），而血清促卵泡激素水平与任何过敏性疾病的患病风险增加显著相关（校正比值比，2.04；95%置信区间，1.01-4.11，P=0.046）。脱氢表雄酮硫酸盐水平与过敏疾病的数量呈显著相关。
本研究结果表明，性激素可能在青春期前儿童过敏疾病的发展中发挥重要作用。
