Wei Xiang-Yu, Luo Shi-Lei, Chen Hui, Liu Shan-Shan, Gong Zhi-Gang, Zhan Song-Hua
Department of Radiology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Department of Acupuncture & Moxibustion, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
J Integr Med. 2022 May;20(3):237-243. doi: 10.1016/j.joim.2022.01.009. Epub 2022 Jan 31.
To investigate the changes in the functional connectivity (FC) in the right insula between migraine without aura (MWoA) and healthy controls by using resting-state functional magnetic resonance imaging (rs-fMRI), and to observe the instant alteration of FC in MWoA during electroacupuncture (EA) stimulation at Shuaigu (GB8).
A total of 30 patients with MWoA (PM group) and 30 healthy controls (HC group) underwent rs-fMRI scans. The PM group underwent a second rs-fMRI scan while receiving EA at GB8. The right insula subregions, including the ventral anterior insula (vAI), dorsal anterior insula (dAI) and posterior insula (PI), were selected as the seed points for FC analysis.
Aberrant FC, including dAI with right postcentral gyrus, PI with left precuneus, was found among PM before EA (PMa), PM during EA (PMb) and HC. Meanwhile, decreased FC between dAI and the right postcentral gyrus was found in the PMa compared to the HC and PMb. Increased FC between the PI and left precuneus was found in the PMa compared to the HC and PMb. Correlation analysis showed that the FC value of the right postcentral gyrus in PMa was negatively correlated with the scores of Hamilton Rating Scale for Depression and Hamilton Rating Scale for Anxiety. The FC value of the left precuneus in PMa was positively correlated with the visual analogue scale score.
The alteration of FC between the right insula subregions and multiple brain regions may be an important index for MWoA. EA at GB8 was able to adjust the FC between the right insula subregions and parietal lobe, namely, the right dAI and right postcentral gyrus, and the right PI and left precuneus, thereby rendering an instant effect in the management of MWoA.
采用静息态功能磁共振成像（rs-fMRI）研究无先兆偏头痛（MWoA）患者与健康对照者右侧脑岛的功能连接（FC）变化，并观察在率谷（GB8）进行电针（EA）刺激时MWoA患者FC的即时改变。
30例MWoA患者（PM组）和30例健康对照者（HC组）接受rs-fMRI扫描。PM组在GB8接受EA刺激时进行第二次rs-fMRI扫描。选取右侧脑岛亚区，包括腹侧前脑岛（vAI）、背侧前脑岛（dAI）和后脑岛（PI）作为FC分析的种子点。
在EA前的PM（PMa）、EA期间的PM（PMb）和HC之间发现异常FC，包括dAI与右侧中央后回、PI与左侧楔前叶。同时，与HC和PMb相比，PMa中dAI与右侧中央后回之间的FC降低。与HC和PMb相比，PMa中PI与左侧楔前叶之间的FC增加。相关性分析显示，PMa中右侧中央后回的FC值与汉密尔顿抑郁量表评分和汉密尔顿焦虑量表评分呈负相关。PMa中左侧楔前叶的FC值与视觉模拟量表评分呈正相关。
右侧脑岛亚区与多个脑区之间FC的改变可能是MWoA的重要指标。在GB8进行EA能够调节右侧脑岛亚区与顶叶之间的FC，即右侧dAI与右侧中央后回、右侧PI与左侧楔前叶之间的FC，从而在MWoA的治疗中产生即时效果。
