Department of General Internal Medicine, The Fourth Hospital of Shijiazhuang (Maternal Hospital Affiliated to Hebei Medical University), Shijiazhuang City, Hebei Province 050031, China.
Department of Diagnostic Ultrasound, The Fourth Hospital of Shijiazhuang (Maternal Hospital Affiliated to Hebei Medical University), Shijiazhuang City, Hebei Province 050031, China.
Steroids. 2022 Aug;184:108993. doi: 10.1016/j.steroids.2022.108993. Epub 2022 Feb 24.
Gestational diabetes mellitus (GDM) is a common pregnancy-related disorder that pregnant women without diabetes develop glucose tolerance during pregnancy. Endothelial dysfunction is the early event of vascular complications of diabetes. However, the role of endothelial dysfunction in GDM remains unknown. In this study, we hypothesize that there is a correlation between endothelial dysfunction and GDM indexes in the patients.
96 GDM patients and 96 gestational week-matched healthy pregnancies with normal glucose tolerance were recruited in our study. The expressions of endothelial function markers, including nitride oxidase (NO) and endothelin-1 (ET-1), as well as flow-mediated dilatation (FMD), were measured. In addition, their correlation in GDM patients were also analyzed using Pearson's correlation analysis.
GDM patients displayed decrease on FMD and serum NO levels with an increase on serum ET-1 secretion in comparison with normal glucose tolerance group. ROC analysis identified the predictive value of FMD, ET-1 and NO for GDM. Furthermore, endothelial dysfunction was correlated with both fasting plasma glucose and plasma glucose levels after 1 h or 2 h of oral glucose tolerance test in GDM patients.
Our data indicated that endothelial dysfunction was associated with GDM, and these markers might serve as potential biomarkers for GDM.
妊娠期糖尿病（GDM）是一种常见的妊娠相关疾病，指妊娠期间无糖尿病的孕妇发生糖耐量异常。内皮功能障碍是糖尿病血管并发症的早期事件。然而，内皮功能障碍在 GDM 中的作用尚不清楚。在本研究中，我们假设患者的内皮功能障碍与 GDM 指标之间存在相关性。
本研究纳入了 96 例 GDM 患者和 96 例血糖正常的妊娠 12 周的健康孕妇。测量了内皮功能标志物，包括一氧化氮（NO）和内皮素-1（ET-1）的表达以及血流介导的扩张（FMD）。此外，还使用 Pearson 相关分析分析了 GDM 患者中它们之间的相关性。
与血糖正常的对照组相比，GDM 患者的 FMD 和血清 NO 水平降低，血清 ET-1 分泌增加。ROC 分析确定了 FMD、ET-1 和 NO 对 GDM 的预测价值。此外，内皮功能障碍与 GDM 患者的空腹血糖和口服葡萄糖耐量试验 1 小时或 2 小时后的血糖水平均相关。
我们的数据表明，内皮功能障碍与 GDM 相关，这些标志物可能作为 GDM 的潜在生物标志物。
