Akhtar Asma, Kazi Tasneem Gul, Afridi Hassan Imran, Khan Mustafa
National Centre of Excellence in Analytical Chemistry, University of Sindh, Jamshoro, 76080, Pakistan.
National Centre of Excellence in Analytical Chemistry, University of Sindh, Jamshoro, 76080, Pakistan.
Regul Toxicol Pharmacol. 2022 Jun;131:105145. doi: 10.1016/j.yrtph.2022.105145. Epub 2022 Feb 24.
Facial cosmetics are the most commonly consumed product, mainly by the women from all over the world irrespective of their age. The facial cosmetics may be contaminated with several toxic elements, which can get absorb on to the facial skin and migrate to the blood vessels. Hence the absorbed toxic elements can cause further adverse effects on the human body. The present study aims to assess the toxic element contents (arsenic, lead, nickel, mercury, and cadmium) in commonly consumed facial cosmetics (face powder, foundation, lightning creams, moisturizer, eye shadow, lipsticks, eyeliner, blush, mascara, sunscreen) and to carry out the risk assessment through different methods. The dermal risk was evaluated as SED, NOAEL, MoS, HQ and ILCR, which is linked with the exposure of selected toxic elements. The total CDDE for all selected elements in facial cosmetic products was found in increasing order as follow: face powder > foundation > lightning creams > moisturizer > eye shadow > lipsticks > eyeliner > blush > mascara > sunscreen. The HQ and HI values for selected elements were found to be < 1 in all facial cosmetics. Whereas the probable MoS of selected toxic elements in all facial cosmetics except eyeliner were found to be 3-4 folds lower than the minimum value of 100 regulated by the WHO.
面部化妆品是消费最为普遍的产品，主要为世界各地的女性所使用，无论其年龄大小。面部化妆品可能会被多种有毒元素污染，这些元素会吸附在面部皮肤上并迁移至血管。因此，被吸收的有毒元素会对人体造成进一步的不良影响。本研究旨在评估常见面部化妆品（粉饼、粉底、美白霜、保湿霜、眼影、口红、眼线笔、腮红、睫毛膏、防晒霜）中的有毒元素含量（砷、铅、镍、汞和镉），并通过不同方法进行风险评估。通过与选定有毒元素的暴露相关的皮肤等效剂量（SED）、无观察到有害作用水平（NOAEL）、安全系数（MoS）、危害商数（HQ）和吸入终生致癌风险（ILCR）来评估皮肤风险。面部化妆品中所有选定元素的总慢性每日膳食暴露量（CDDE）按升序排列如下：粉饼＞粉底＞美白霜＞保湿霜＞眼影＞口红＞眼线笔＞腮红＞睫毛膏＞防晒霜。在所有面部化妆品中，选定元素的HQ和危害指数（HI）值均＜1。然而，除眼线笔外，所有面部化妆品中选定有毒元素的可能安全系数比世界卫生组织规定的最低值100低3至4倍。
