Mercan Selda, Zengin Simge, Kilic Mihriban Dilan, Yayla Murat
Istanbul University- Cerrahpaşa Institute of Forensic Sciences and Legal Medicine, Department of Science, Istanbul University- Cerrahpaşa, 34500, Buyukcekmece, Istanbul, Türkiye.
Biol Trace Elem Res. 2024 Apr;202(4):1816-1828. doi: 10.1007/s12011-023-03791-0. Epub 2023 Aug 10.
Toxic elements that pose a potential threat to human health are found as impurities in various cosmetic products. In this study, the inorganic profile of 19 elements (Li, B, Mg, Al, Cr, Mn, Co, Ni, Cu, Zn, As, Se, Sr, Mo, Cd, Sb, Ba, Hg, and Pb) in 90 cosmetic products (lipsticks, lip glosses, lip pencils and eye shadows) were detected by inductively coupled plasma-mass spectrometry after microwave acid digestion method and hazard indices (HI) of 9 toxic elements (Pb, Cd, Cr, Ni, Co, As, Hg, Sb, and Al) were calculated for the assessment of theoretical health risk. Satisfactory method performance parameters were found for each analyte. The results were compared with the maximum permissible limits set by regulatory agencies; 38 of 41 lip products (92.68%) and all eye shadows (n = 49) exceeded the established limits. The HI was found to be ≥ 1 in 82.76% of lip products for oral exposure, whereas HI was ≤ 1 for dermal exposure in all lip products (n = 41) and only one eye shadow sample was ≥ 1 (2.04%). Remarkable results were also detected for 19 elements in this study, which conducted a comprehensive inorganic profiling for the first time. Wide-range concentrations of Mg, Al, Ba, Mn, Cu, Zn, and Sr elements were remarkable. HI values were firstly brought out in this study, although Al, as a well-known toxic element, has not been listed in regulations yet. In conclusion, it is obviously seen that continuous monitoring of cosmetics is crucial not only for toxic elements but also for other essential or non-toxic elements to prevent consumers from long-term exposure.
在各类化妆品中发现了对人体健康构成潜在威胁的有毒元素杂质。在本研究中，采用微波酸消解后电感耦合等离子体质谱法检测了90种化妆品（口红、唇彩、唇线笔和眼影）中19种元素（锂、硼、镁、铝、铬、锰、钴、镍、铜、锌、砷、硒、锶、钼、镉、锑、钡、汞和铅）的无机成分，并计算了9种有毒元素（铅、镉、铬、镍、钴、砷、汞、锑和铝）的危害指数（HI），以评估理论健康风险。各分析物均获得了令人满意的方法性能参数。将结果与监管机构设定的最大允许限值进行了比较；41种唇部产品中有38种（92.68%）以及所有眼影（n = 49）超过了既定限值。对于口服暴露，82.76%的唇部产品的HI≥1，而对于所有唇部产品（n = 41）的皮肤暴露，HI≤1，只有一个眼影样品的HI≥1（2.04%）。本研究首次对19种元素进行了全面的无机分析，也检测到了显著结果。镁、铝、钡、锰、铜、锌和锶元素的浓度范围很广，值得关注。尽管铝作为一种知名的有毒元素尚未列入法规，但本研究首次提出了HI值。总之，显而易见的是，持续监测化妆品不仅对于有毒元素而且对于其他必需或无毒元素都至关重要，以防止消费者长期接触。
