Simonsson B O, Berggren-Stiksa A G, Berggren E M, Stiksa G
Ann Allergy. 1978 Jun;40(6):409-12.
Racemic epinephrine in doses of 4.5 and 9 mg were administered by IPPV with a Bird Mark 8 in a double-blind, crossover study on consecutive days to 12 normal subjects and to 12 patients with airways obstruction. Normal subjects did not react with any clinically significant change in pulse rate or blood pressure. PEFR in the patients increased by an average of 35% from 5 to 60 minutes after 4.5 mg and by 44-42% after 9 mg. The increase after the larger dose was significantly larger five minutes after inhalation. There was no clinically significant change in pulse rate or blood pressure but a slightly greater frequency of mild side effects among the normal subjects and after the larger dose.
在一项双盲交叉研究中，连续数天使用Bird Mark 8型间歇正压通气机，对12名正常受试者和12名气道阻塞患者给予4.5毫克和9毫克剂量的消旋肾上腺素。正常受试者的脉搏率或血压未出现任何具有临床意义的变化。患者的呼气峰流速（PEFR）在给予4.5毫克剂量后5至60分钟平均增加35%，给予9毫克剂量后增加44%至42%。吸入较大剂量后5分钟，其增加幅度明显更大。脉搏率或血压未出现具有临床意义的变化，但正常受试者以及使用较大剂量后出现轻度副作用的频率略高。
