Gao Fangli, Sun Mengmeng, Zhang Jie, Chang Yi, Gao Weihua, Ma Guanglei, Ma Xiaoming, Guo Yuming
School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang, Henan 453007, China.
Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, Henan Normal University, Xinxiang, Henan 453007, China.
J Colloid Interface Sci. 2022 Jun 15;616:369-378. doi: 10.1016/j.jcis.2022.02.060. Epub 2022 Feb 16.
Chirality-based nanomaterials, especially semiconductors nanoparticles (NPs), are the emerging research in biomedicine field. Herein, chiral manganese dioxide (L/D-MnO) NPs were synthesized by using threonine molecules as chiral ligands. Then cisplatin loaded L/D-MnO (L/D-MnO@Pt) NPs were successfully constructed based on the high specific surface area of L/D-MnO NPs. L/D-MnO@Pt NPs could be specifically internalized by tumor cells and efficiently deplete the glutathione (GSH) through redox reaction to release Mn and Pt. The released Mn exhibited strong chemodynamic effect through Fenton-like reaction. The depletion of GSH further improved the chemodynamic therapy (CDT) efficiency. The combination of the CDT of Mn with the chemotherapy of Pt considerably enhanced the tumor therapy efficiency. It was particularly noteworthy that L/D-MnO@Pt NPs showed chirality-based different internalization by tumor cells and further led to different tumor cell ablation effects, in which D-MnO@Pt NPs exhibited stronger therapeutic efficiency than L-MnO@Pt NPs. These findings provided deep insights for novel biomedical applications of chirality-based semiconductors NPs.
基于手性的纳米材料，尤其是半导体纳米粒子（NPs），是生物医学领域新兴的研究方向。在此，以苏氨酸分子作为手性配体合成了手性二氧化锰（L/D-MnO）纳米粒子。然后，基于L/D-MnO纳米粒子的高比表面积，成功构建了负载顺铂的L/D-MnO（L/D-MnO@Pt）纳米粒子。L/D-MnO@Pt纳米粒子能够被肿瘤细胞特异性内化，并通过氧化还原反应有效消耗谷胱甘肽（GSH）以释放锰和铂。释放出的锰通过类芬顿反应表现出强大的化学动力学效应。GSH的消耗进一步提高了化学动力学疗法（CDT）的效率。锰的CDT与铂的化疗相结合显著增强了肿瘤治疗效果。特别值得注意的是，L/D-MnO@Pt纳米粒子对肿瘤细胞表现出基于手性的不同内化作用，并进一步导致不同的肿瘤细胞消融效果，其中D-MnO@Pt纳米粒子表现出比L-MnO@Pt纳米粒子更强的治疗效率。这些发现为基于手性的半导体纳米粒子在新型生物医学应用方面提供了深刻见解。
