Taziki Balajelini M H, Vakili M A, Rajabi A, Mohammadi M, Tabarraei A, Hosseini S M
Department of Otorhinolaryngology, School of Medicine, Golestan University of Medical Sciences, Gorgan, Iran.
Department of Family and Community Medicine, School of Medicine, Golestan, University of Medical Sciences, Gorgan, Iran.
J Laryngol Otol. 2022 Feb 9:1-8. doi: 10.1017/S0022215121003935.
This study aimed to determine the association of some demographic and clinical factors with recovery from olfactory and gustatory dysfunction in coronavirus disease 2019 patients in Iran.
This prospective cohort study was performed on 242 coronavirus disease 2019 patients with olfactory and gustatory dysfunction. The time from onset to recovery for olfactory and gustatory dysfunction was estimated by the Kaplan-Meier estimator.
After six months, 239 patients (98.8 per cent) had completely recovered from olfactory dysfunction. Olfactory and gustatory dysfunction symptoms resolved in 80.99 per cent and 83.56 per cent of the patients, respectively, within the first 30 days of symptom onset. Mean recovery time for olfactory dysfunction (35.07 ± 4.25 days) was significantly longer in those infected during the first epidemic wave compared with those infected during the second wave (21.65 ± 2.05 days) (p = 0.004). A similar pattern in recovery time was observed for cases of gustatory dysfunction (p = 0.005).
The recovery rate for coronavirus disease 2019 related olfactory and gustatory dysfunction is high within the first month of symptom onset.
本研究旨在确定伊朗2019冠状病毒病患者的一些人口统计学和临床因素与嗅觉和味觉功能障碍恢复之间的关联。
对242例患有嗅觉和味觉功能障碍的2019冠状病毒病患者进行了这项前瞻性队列研究。嗅觉和味觉功能障碍从发病到恢复的时间通过Kaplan-Meier估计器进行估算。
六个月后，239例患者（98.8%）嗅觉功能障碍完全恢复。在症状出现的前30天内，分别有80.99%和83.56%的患者嗅觉和味觉功能障碍症状得到缓解。与第二波感染患者相比，第一波疫情期间感染的患者嗅觉功能障碍的平均恢复时间（35.07±4.25天）明显更长（21.65±2.05天）（p=0.004）。味觉功能障碍病例的恢复时间也观察到类似模式（p=0.005）。
2019冠状病毒病相关的嗅觉和味觉功能障碍在症状出现的第一个月内恢复率很高。
