Burghuber O C, Punzengruber C, Sinzinger H, Haber P, Silberbauer K
Chest. 1986 Jul;90(1):34-8. doi: 10.1378/chest.90.1.34.
Platelet activating effect of cigarette smoking appears to be important in the development of atherosclerosis. We previously demonstrated a reduced sensitivity of platelets to exogenous prostacyclin (PGI2) in vitro from patients with proven atherosclerotic disease, indicating a possible role of altered platelet function in the development of atherosclerosis. We now hypothesize that cigarette smoking might be an important cause of altered platelet sensitivity to PGI2 observed in patients with atherosclerosis. To test this hypothesis, the response of platelets to exogenous PGI2 was tested in chronic smokers and non-smokers, prior to and after smoking two cigarettes (active smoking) and prior to and after exposure to a tobacco smoke-contaminated atmosphere (passive smoking). This study indicates that platelets of chronic smokers are less sensitive to exogenous PGI2 than platelets of non-smokers. In addition, active as well as passive smoking decreases platelet sensitivity to PGI2 in non-smokers, whereas chronic smokers exhibit no further decline. We conclude that decreased platelet sensitivity to PGI2 might be an important contributing factor to the altered platelet function observed in patients with atherosclerosis.
吸烟对血小板的激活作用在动脉粥样硬化的发展过程中似乎起着重要作用。我们之前证实，在患有经证实的动脉粥样硬化疾病的患者中，体外血小板对外源性前列环素（PGI2）的敏感性降低，这表明血小板功能改变在动脉粥样硬化的发展中可能起到一定作用。我们现在推测，吸烟可能是在动脉粥样硬化患者中观察到的血小板对PGI2敏感性改变的一个重要原因。为了验证这一假设，我们对慢性吸烟者和非吸烟者在吸两支香烟之前和之后（主动吸烟）以及在暴露于受烟草烟雾污染的环境之前和之后（被动吸烟），测试了血小板对外源性PGI2的反应。这项研究表明，慢性吸烟者的血小板对外源性PGI2的敏感性低于非吸烟者。此外，主动吸烟和被动吸烟都会降低非吸烟者血小板对PGI2的敏感性，而慢性吸烟者的血小板敏感性则不会进一步下降。我们得出结论，血小板对PGI2敏感性降低可能是动脉粥样硬化患者中观察到的血小板功能改变的一个重要促成因素。
