Kim Hak-Jun, Lee Gi-Wook, Son Jin-Wha, Shin Kihyuk, Kim Hoon-Soo, Ko Hyun-Chang, Kim Byung-Soo, Kim Moon-Bum
Department of Dermatology, School of Medicine, Pusan National University, Busan, Korea.
Department of Dermatology, Pusan National University Yangsan Hospital, Yangsan, Korea.
Ann Dermatol. 2022 Feb;34(1):34-39. doi: 10.5021/ad.2022.34.1.34. Epub 2022 Jan 27.
Pigmented purpuric dermatosis (PPD) is a chronic disorder characterized by distinct petechial hemorrhage and brownish pigmentation. The cause of PPD is unclear, but several underlying conditions are associated with it. Previous reports suggest that venous insufficiency (VI) might be related to PPD; however, a clear correlation remains unelucidated.
To elucidate the causal relationship between PPD and VI.
A total 118 patients diagnosed with PPD in the Department of Dermatology, Pusan National University Hospital from November 2006 to July 2019 were retrospectively reviewed. Doppler ultrasonography of the lower extremities was performed in 56 PPD patients, who were then divided into two groups: PPD with and without VI. We compared the clinical features between the two groups. In the PPD with VI group, we assessed the correspondence ratios between PPD and VI lateralities, and between the PPD distribution and the veins involved.
VI was detected in 35 of the 56 patients (62.5%). The PPD with VI group was significantly associated with wider distribution, darker coloration and longer disease duration. There was a positive correlation of laterality between PPD and VI, and between PPD distribution and the vein involved.
This findings suggest that VI is a clear provoker of PPD.
色素性紫癜性皮病（PPD）是一种慢性疾病，其特征为明显的瘀点出血和褐色色素沉着。PPD的病因尚不清楚，但有几种潜在情况与之相关。先前的报告表明静脉功能不全（VI）可能与PPD有关；然而，明确的相关性仍未阐明。
阐明PPD与VI之间的因果关系。
回顾性分析了2006年11月至2019年7月在釜山国立大学医院皮肤科诊断为PPD的118例患者。对56例PPD患者进行了下肢多普勒超声检查，然后将其分为两组：伴有和不伴有VI的PPD。我们比较了两组之间的临床特征。在伴有VI的PPD组中，我们评估了PPD与VI的左右侧对应率，以及PPD分布与受累静脉之间的对应率。
56例患者中有35例（62.5%）检测到VI。伴有VI的PPD组与更广泛的分布、更深的颜色和更长的病程显著相关。PPD与VI之间、PPD分布与受累静脉之间存在左右侧的正相关。
这些发现表明VI是PPD的明确诱发因素。
