Hu Shaojun, Xing Hongyuan, Zhang Jiangnan, Zhu Zemin, Yin Ying, Zhang Ning, Qi Yiying
Department of Orthopedics, 2nd Affiliated Hospital, School of Medicine, Zhejiang University, 88 Jiefang Road, Zhejiang, 310009 Hangzhou, China.
Department of Orthopedics Surgery, Wenling 1st People's Hospital, 190 Taiping South Road, Wenling, 317500 Zhejiang, China.
Stem Cells Int. 2022 Feb 18;2022:7538025. doi: 10.1155/2022/7538025. eCollection 2022.
Intervertebral disc (IVD) degenerative disease is a common health problem worldwide. Administration of mesenchymal stem cells (MSCs) in intervertebral disc degeneration (IVDD) has been widely explored in recent years. However, transplantation of MSCs is restricted by several factors. Currently, paracrine signaling is one of the main mechanisms by which MSCs play a therapeutic role in disc regeneration. Extracellular vehicles (EVs) are the main paracrine products of MSCs. They show great potential as an effective alternative to MSCs and play immunomodulation roles such as anti-inflammatory effects, antioxidative stress, antiapoptosis, and antiextracellular matrix (ECM) degradation during treatment of IVDD. This review focuses on the immunomodulatory effect of MSC EVs and their potential applications.
椎间盘退变疾病是全球范围内常见的健康问题。近年来，间充质干细胞（MSCs）在椎间盘退变（IVDD）中的应用已得到广泛研究。然而，MSCs的移植受到多种因素的限制。目前，旁分泌信号是MSCs在椎间盘再生中发挥治疗作用的主要机制之一。细胞外囊泡（EVs）是MSCs的主要旁分泌产物。它们作为MSCs的有效替代物具有巨大潜力，并且在IVDD治疗过程中发挥免疫调节作用，如抗炎作用、抗氧化应激、抗凋亡和抗细胞外基质（ECM）降解。本综述重点关注MSC EVs的免疫调节作用及其潜在应用。
