Mercut Razvan, Mercut Irina Maria, Glodeanu Adina Dorina, Ionescu Mihaela, Turcu Adina, Stefanescu-Dima Alin, Ciurea Marius Eugen
Department of Plastic Surgery and Reconstructive Microsurgery, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.
Department of Ophthalmology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.
Exp Ther Med. 2022 Mar;23(3):234. doi: 10.3892/etm.2022.11159. Epub 2022 Jan 21.
During the past few years, several studies have demonstrated that head and neck carcinomas present more aggressive forms for smokers, relative to non-smokers. Our aim was to investigate the tumor aggressiveness for patients with eyelid carcinomas, in relation to tobacco consumption, as well as other demographic and clinical data. For 98 patients with eyelid carcinomas, we studied the relationship between the duration of their symptoms and their tumor stage at first diagnosis, trying to determine potential correlations with smoking status and several other clinical parameters. Our data revealed that, for the same duration of symptoms, tobacco consumers tended to have higher tumor stages, which did not correlate with other variables. For early diagnosed tumors, within the first year of symptoms, smokers presented 6.044 times higher odds to exhibit more advanced tumor stages, compared to non-smokers, and this value decreased to 4.501, up to 5 years of the presence of symptoms (P<0.05). We also noted that, for smokers, an increased age was associated with increased tumor stages, which was opposed to non-smokers, regardless of their symptom duration [average odds ratio (OR) 1.122, P<0.05]. Tumor aggressiveness was therefore associated with tobacco consumption, leading to an increased risk of developing more aggressive forms of eyelid carcinomas for smokers, compared to non-smokers.
在过去几年中，多项研究表明，相对于不吸烟者，头颈部癌在吸烟者中表现出更具侵袭性的形式。我们的目的是研究眼睑癌患者的肿瘤侵袭性与烟草消费以及其他人口统计学和临床数据之间的关系。对于98例眼睑癌患者，我们研究了他们症状持续时间与首次诊断时肿瘤分期之间的关系，试图确定与吸烟状况和其他几个临床参数的潜在相关性。我们的数据显示，在相同症状持续时间内，烟草消费者的肿瘤分期往往更高，这与其他变量无关。对于在症状出现的第一年内早期诊断的肿瘤，与不吸烟者相比，吸烟者出现更晚期肿瘤分期的几率高出6.044倍，而在症状出现长达5年时，这一数值降至4.501（P<0.05）。我们还注意到，对于吸烟者，年龄增长与肿瘤分期增加相关，而对于不吸烟者则不然，无论其症状持续时间如何[平均比值比（OR）为1.122，P<0.05]。因此，肿瘤侵袭性与烟草消费相关，与不吸烟者相比，吸烟者患更具侵袭性形式的眼睑癌的风险增加。
