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与香烟致癌物相关的肿瘤发病机制

Neoplastic Pathogenesis Associated with Cigarette Carcinogens.

作者信息

Hussain Azhar, Dulay Parmvir, Rivera Megan N, Aramouni Carla, Saxena Vishal

机构信息

Epidemiology and Public Health, Xavier University School of Medicine, Oranjestad, ABW.

Internal Medicine, Xavier University School of Medicine, Oranjestad, ABW.

出版信息

Cureus. 2019 Jan 25;11(1):e3955. doi: 10.7759/cureus.3955.

Abstract

Cigarette smoke is widely regarded as a carcinogenic agent; thus, the incidence of relative neoplasms correlates to cigarette smoking (CS) on a global level. While CS is most commonly associated with carcinomas of the upper and lower respiratory tracts, studies have also associated CS with the pathogenesis of a variety of non-respiratory related neoplasms. The tobacco smoke emitted from cigarettes contains carcinogenic substances that can be harmful to the normal physiology of the human body. This study will elaborate on the incidence and etiology of carcinomas, as well as discuss, in detail, the role of tobacco in the pathogenesis of oral, esophageal, lung, gastric, pancreatic, renal, and bladder carcinomas.

摘要

香烟烟雾被广泛认为是一种致癌物质;因此,在全球范围内,相关肿瘤的发病率与吸烟相关。虽然吸烟最常与上、下呼吸道癌症相关,但研究也将吸烟与多种非呼吸道相关肿瘤的发病机制联系起来。香烟释放出的烟草烟雾含有致癌物质,会对人体正常生理机能造成损害。本研究将阐述各类癌症的发病率和病因,并详细讨论烟草在口腔癌、食管癌、肺癌、胃癌、胰腺癌、肾癌和膀胱癌发病机制中的作用。

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