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Neoplastic Pathogenesis Associated with Cigarette Carcinogens.与香烟致癌物相关的肿瘤发病机制
Cureus. 2019 Jan 25;11(1):e3955. doi: 10.7759/cureus.3955.
2
The changing cigarette, 1950-1995.变化中的香烟,1950 - 1995年
J Toxicol Environ Health. 1997 Mar;50(4):307-64. doi: 10.1080/009841097160393.
3
Tobacco and tobacco smoke.烟草及烟草烟雾。
Semin Oncol. 1976 Mar;3(1):5-15.
4
Selective clonal expansion and microenvironmental permissiveness in tobacco carcinogenesis.烟草致癌中的选择性克隆扩增与微环境许可性
Oncogene. 2002 Oct 21;21(48):7392-411. doi: 10.1038/sj.onc.1205800.
5
Cigarettes and cigarette smoking.香烟与吸烟。
Clin Chest Med. 1991 Dec;12(4):631-42.
6
[The awareness of carcinogenic effect of tobacco smoke--a questionnaire survey of students and employees of Collegium Medicum of Nicolaus Copernicus University].[对烟草烟雾致癌作用的认知——哥白尼大学医学院学生和员工问卷调查]
Przegl Lek. 2012;69(10):904-7.
7
DNA solution(R) in cigarette filters reduces polycyclic aromatic hydrocarbon (PAH) levels in mainstream tobacco smoke.香烟滤嘴中的DNA溶液(R)可降低主流烟草烟雾中的多环芳烃(PAH)含量。
Food Chem Toxicol. 2007 Sep;45(9):1752-6. doi: 10.1016/j.fct.2007.03.007. Epub 2007 Mar 19.
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Determination of carcinogenic tobacco-specific nitrosamines in mainstream smoke from U.S.-brand and non-U.S.-brand cigarettes from 14 countries.14个国家美国品牌和非美国品牌香烟主流烟气中致癌性烟草特有亚硝胺的测定
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[Effect of cigarette smoking and/or N-bis(2-hydroxypropyl)nitrosamine (DHPN) on the development of lung and pleural tumors in rats induced by administration of asbestos].[吸烟和/或N-双(2-羟丙基)亚硝胺(DHPN)对石棉诱导的大鼠肺和胸膜肿瘤发生发展的影响]
Sangyo Igaku. 1991 Mar;33(2):81-93. doi: 10.1539/joh1959.33.81.
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[Carcinogenic effect of tobacco smoke].[烟草烟雾的致癌作用]
Rocz Panstw Zakl Hig. 2009;60(4):299-310.

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Shared Lifestyle-Related Risk Factors of Cardiovascular Disease and Cancer: Evidence for Joint Prevention.心血管疾病和癌症的共同生活方式相关风险因素:联合预防的证据。
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Integrated clinical genomic analysis reveals xenobiotic metabolic genes are downregulated in meningiomas of current smokers.整合临床基因组分析显示,外源性代谢基因在现吸烟人群的脑膜瘤中表达下调。
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Lower Prevalence of Human Papillomavirus in Head and Neck Squamous Cell Carcinoma in Middle Eastern Population: Clinical Implications for Diagnosis and Prevention.中东人群头颈部鳞状细胞癌中人乳头瘤病毒的低流行率:对诊断和预防的临床意义
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Thioredoxin as a novel sensitive marker of biological stress response in smoking.硫氧还蛋白作为吸烟中生物应激反应的新型敏感标志物。
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8
Protective Effects of Bark Extract and Nicotine on Cigarette Smoke-induced Oxidative Stress in Keratinocytes.树皮提取物和尼古丁对香烟烟雾诱导的角质细胞氧化应激的保护作用。
In Vivo. 2020 Jul-Aug;34(4):1835-1843. doi: 10.21873/invivo.11978.

本文引用的文献

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Surveillance for Cancers Associated with Tobacco Use - United States, 2010-2014.烟草使用相关癌症监测 - 美国,2010-2014 年。
MMWR Surveill Summ. 2018 Nov 2;67(12):1-42. doi: 10.15585/mmwr.ss6712a1.
2
Renal cell carcinoma risk associated with lower intake of micronutrients.与低摄入微量营养素相关的肾细胞癌风险。
Cancer Med. 2018 Aug;7(8):4087-4097. doi: 10.1002/cam4.1639. Epub 2018 Jul 2.
3
Smoking and alcohol drinking in relation to the risk of esophageal squamous cell carcinoma: A population-based case-control study in China.吸烟和饮酒与食管鳞癌风险的关系:中国基于人群的病例对照研究。
Sci Rep. 2017 Dec 8;7(1):17249. doi: 10.1038/s41598-017-17617-2.
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Epidemiology of urothelial carcinoma.尿路上皮癌的流行病学
Int J Urol. 2017 Oct;24(10):730-734. doi: 10.1111/iju.13376. Epub 2017 May 21.
5
Increasing popularity of waterpipe tobacco smoking and electronic cigarette use: Implications for oral healthcare.水烟烟草和电子烟使用日益普及:对口腔保健的影响。
J Periodontal Res. 2017 Oct;52(5):813-823. doi: 10.1111/jre.12458. Epub 2017 Apr 10.
6
Cigarette Smoking and Pancreatic Cancer Survival.吸烟与胰腺癌生存率
J Clin Oncol. 2017 Jun 1;35(16):1822-1828. doi: 10.1200/JCO.2016.71.2026. Epub 2017 Mar 30.
7
Renal cell carcinoma.肾细胞癌。
Nat Rev Dis Primers. 2017 Mar 9;3:17009. doi: 10.1038/nrdp.2017.9.
8
Molecular Pathogenesis of Pancreatic Cancer.胰腺癌的分子发病机制
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9
Distant metastasis from oral cancer: A review and molecular biologic aspects.口腔癌的远处转移:综述及分子生物学方面
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10
Lauren classification and individualized chemotherapy in gastric cancer.胃癌的劳伦分类与个体化化疗
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与香烟致癌物相关的肿瘤发病机制

Neoplastic Pathogenesis Associated with Cigarette Carcinogens.

作者信息

Hussain Azhar, Dulay Parmvir, Rivera Megan N, Aramouni Carla, Saxena Vishal

机构信息

Epidemiology and Public Health, Xavier University School of Medicine, Oranjestad, ABW.

Internal Medicine, Xavier University School of Medicine, Oranjestad, ABW.

出版信息

Cureus. 2019 Jan 25;11(1):e3955. doi: 10.7759/cureus.3955.

DOI:10.7759/cureus.3955
PMID:30956908
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6436676/
Abstract

Cigarette smoke is widely regarded as a carcinogenic agent; thus, the incidence of relative neoplasms correlates to cigarette smoking (CS) on a global level. While CS is most commonly associated with carcinomas of the upper and lower respiratory tracts, studies have also associated CS with the pathogenesis of a variety of non-respiratory related neoplasms. The tobacco smoke emitted from cigarettes contains carcinogenic substances that can be harmful to the normal physiology of the human body. This study will elaborate on the incidence and etiology of carcinomas, as well as discuss, in detail, the role of tobacco in the pathogenesis of oral, esophageal, lung, gastric, pancreatic, renal, and bladder carcinomas.

摘要

香烟烟雾被广泛认为是一种致癌物质;因此,在全球范围内,相关肿瘤的发病率与吸烟相关。虽然吸烟最常与上、下呼吸道癌症相关,但研究也将吸烟与多种非呼吸道相关肿瘤的发病机制联系起来。香烟释放出的烟草烟雾含有致癌物质,会对人体正常生理机能造成损害。本研究将阐述各类癌症的发病率和病因,并详细讨论烟草在口腔癌、食管癌、肺癌、胃癌、胰腺癌、肾癌和膀胱癌发病机制中的作用。