高 SIRPA 表达预示着食管癌患者预后不良，并与免疫浸润相关。
High SIRPA Expression Predicts Poor Prognosis and Correlates with Immune Infiltrates in Patients with Esophageal Carcinoma.
机构信息
Department of Endoscopy, The First Hospital of Jilin University, Changchun 130021, China.
Department of General Medicine, The First Hospital of Jilin University, Changchun 130021, China.
出版信息
J Healthc Eng. 2022 Feb 16;2022:3565676. doi: 10.1155/2022/3565676. eCollection 2022.
BACKGROUND
Signal regulatory protein alpha (SIRPA) is an inhibitory receptor expressed in macrophages and a potential therapeutic target in cancers. This study aims to investigate the functional role of SIRPA in esophageal carcinoma (ESCA).
METHODS
Based on the Oncomine and The Cancer Genome Atlas (TCGA) database, SIRPA expression and clinical value were determined. Gene set enrichment analysis (GSEA) was performed to predict the mechanism underlying the oncogene role of SIRPA. Spearman's correlation analysis was used to analyze the effects of SIRPA on the molecular relationship and immune landscape.
RESULTS
SIRPA was highly expressed across Oncomine and TCGA databases and correlated with poor overall survival and disease-specific survival. There was an expression difference among clinical characteristics. Functional annotation showed that cancer-related biological function and pathways were enriched in the high SIRPA expression group. Besides, SIRPA strongly and extensively affected the immune infiltrates.
CONCLUSION
SIRPA might be an oncogene and a target of immunotherapy in ESCA.
背景
信号调节蛋白 alpha（SIRPA）是巨噬细胞中表达的抑制性受体，也是癌症治疗的潜在靶点。本研究旨在探讨 SIRPA 在食管癌（ESCA）中的功能作用。
方法
基于 Oncomine 和癌症基因组图谱（TCGA）数据库，确定了 SIRPA 的表达和临床价值。进行基因集富集分析（GSEA）以预测 SIRPA 作为致癌基因的作用机制。采用 Spearman 相关分析来分析 SIRPA 对分子关系和免疫景观的影响。
结果
SIRPA 在 Oncomine 和 TCGA 数据库中高表达，与总生存期和疾病特异性生存期不良相关。在临床特征中存在表达差异。功能注释表明，高 SIRPA 表达组中富集了与癌症相关的生物学功能和途径。此外，SIRPA 强烈且广泛地影响免疫浸润。
结论
SIRPA 可能是 ESCA 的致癌基因和免疫治疗的靶点。
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