State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, Department of Nephrology, The First Affiliated Hospital of Xinjiang Medical University, Urumqi 830011, China.
State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, Department of Liver Transplantation & Laparoscopic Surgery, The First Affiliated Hospital of Xinjiang Medical University, Urumqi 830011, China.
J Healthc Eng. 2022 Feb 18;2022:7027777. doi: 10.1155/2022/7027777. eCollection 2022.
Diabetes mellitus (DM) has become a major medical and health problem in my country and even the world. Doctors and patients have gradually realized that a new type of metabolic surgery is a way to treat diabetes. The operation is relatively simple, and the effect of the operation is no less than that of the gastric shunt. The initial hypothesis could not fully explain the blood pressure and blood sugar reduction mechanism in waist and abdominal surgery. According to requirements, they were divided into the sleeve gastrectomy group (SG group, = 10) and sham operation group (SS group, = 10), and corresponding measures were taken. Observe their weight changes; perform an oral glucose tolerance test (GB) before surgery and at 2, 8, and 16 weeks after surgery to evaluate the effect of surgery on improving the glucose metabolism. The postoperative GLP-1 specificity curve was detected in the two groups of patients; the immunohistochemical method was used to detect the postoperative changes of the digestive tract l cells in the two groups; RT-PCR was used to detect the mRNA transcription level of the digestive tract GLP-1 receptor. The bodyweight was significantly different 4 weeks after the operation. Food intake and bodyweight were not significantly different between the SG and SS groups. FBG: one week after operation, the SG group was significantly smaller than the SS group. The SS group was significantly lower than the SG group at 12 weeks after operation, and the SS group was significantly lower than the SG group at 14 weeks after operation. The transcription levels of c-kit mRNA and SCF mRNA in jejunum and ileum tissues are significantly different: the transcription levels of c-kit mRNA and SCF mRNA in the SG group are higher than those in the SS group, jejunum and ileum in the SG group. The number of cell 1 was significantly greater than that of the SS group. Sleeve gastrectomy can improve the regulation of the glucose metabolism in diabetic rats. The increase in small bowel motility may be related to the increase in ICC cells, intestinal cells, and GLP after gastric sleeve resection. The increase is in -1R and faster insoluble CHM in bowel motility. It has better contact with cell 1 and GLP-1R and stimulates cell 1 to secrete GLP-1.
糖尿病（DM）已成为我国乃至世界的主要医学和健康问题。医生和患者逐渐认识到，一种新型代谢手术是治疗糖尿病的一种方法。手术相对简单，手术效果不亚于胃分流术。最初的假设不能完全解释腹部手术降低血压和血糖的机制。根据要求，他们被分为袖状胃切除术组（SG 组，n=10）和假手术组（SS 组，n=10），并采取相应措施。观察体重变化；术前及术后 2、8、16 周行口服葡萄糖耐量试验（GB），评价手术改善葡萄糖代谢的效果。检测两组患者术后 GLP-1 特异性曲线；免疫组织化学法检测两组术后消化道 l 细胞变化；RT-PCR 检测消化道 GLP-1 受体 mRNA 转录水平。术后 4 周体重差异有统计学意义。SG 组和 SS 组之间的食物摄入量和体重无显著差异。FBG：术后一周，SG 组明显小于 SS 组。术后 12 周 SS 组明显低于 SG 组，术后 14 周 SS 组明显低于 SG 组。空肠和回肠组织 c-kitmRNA 和 SCFmRNA 转录水平差异有统计学意义：SG 组 c-kitmRNA 和 SCFmRNA 转录水平明显高于 SS 组，空肠和回肠组织中 SG 组的细胞 1 数明显多于 SS 组。袖状胃切除术可改善糖尿病大鼠的葡萄糖代谢调节。小肠蠕动增加可能与胃袖切除术后 ICC 细胞、肠细胞和 GLP-1 增加有关。-1R 更快，肠内 CHM 更快与细胞 1 和 GLP-1R 接触更充分，刺激细胞 1 分泌 GLP-1。
