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台湾地区新冠肺炎防治分析。

Analysis of COVID-19 prevention and treatment in Taiwan.

作者信息

Chiu Yu-Jen, Chiang Jo-Hua, Fu Chih-Wei, Hour Mann-Jen, Ha Hai-Anh, Kuo Sheng-Chu, Lin Jen-Jyh, Cheng Ching-Chang, Tsai Shih-Chang, Lo Yu-Shiang, Juan Yu-Ning, Cheng Yih-Dih, Yang Jai-Sing, Tsai Fuu-Jen

机构信息

Division of Plastic and Reconstructive Surgery, Department of Surgery, Taipei Veteran General Hospital, Taipei 11217, Taiwan.

Department of Surgery, School of Medicine, National Yang Ming University, Taipei 11217, Taiwan.

出版信息

Biomedicine (Taipei). 2021 Mar 1;11(1):1-18. doi: 10.37796/2211-8039.1185. eCollection 2021.

DOI:10.37796/2211-8039.1185
PMID:35223390
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8823471/
Abstract

Coronavirus disease 2019 (COVID-19) has been spreading worldwide with a mind-boggling speed. According to a statement from World Health Organization (WHO), COVID-19 has infected more than six billions people and caused more than one and half million passing in the world. Based on previous experience with SARS, the Taiwanese government had decided to block viral transmission during its early stages. This review sums up the clinical characteristics, Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) viral infection process, diagnostic methods, preventive strategy, and the executive proportions of COVID-19, as well as the name-based mask distribution system (NBMDS) in Taiwan. We also give a review of the conceivable sub-atomic pharmacologic systems against SARS-CoV-2 specialists and the blend of remdesivir (GS-5734), chloroquine (CQ), and hydroxychloroquine (HCQ). Lastly, we summarized the therapeutic agents against COVID-19 as mentioned by COVID-19 treatment guidelines. In this review, development of novel anti-SARS-CoV-2 viral agents, vaccines for COVID-19 therapy or an effective combination therapy can be expected based on all the information accumulated. Last but not least, we might want to stretch out our best respects to all medical providers in their worldwide battle against COVID-19.

摘要

2019冠状病毒病（COVID-19）一直在以惊人的速度在全球传播。根据世界卫生组织（WHO）的一份声明，COVID-19已感染全球超过60亿人，并导致超过150万人死亡。基于之前应对严重急性呼吸综合征（SARS）的经验，台湾地区政府决定在早期阶段阻断病毒传播。本综述总结了COVID-19的临床特征、严重急性呼吸综合征冠状病毒2（SARS-CoV-2）病毒感染过程、诊断方法、预防策略以及在台湾地区的实施情况，还有基于姓名的口罩分配系统（NBMDS）。我们还综述了针对SARS-CoV-2病原体可能的分子药理学机制以及瑞德西韦（GS-5734）、氯喹（CQ）和羟氯喹（HCQ）的联合使用情况。最后，我们总结了COVID-19治疗指南中提到的针对COVID-19的治疗药物。在本综述中，基于积累的所有信息，有望开发出新型抗SARS-CoV-2病毒药物、用于COVID-19治疗的疫苗或有效的联合治疗方法。最后但同样重要的是，我们要向全球所有抗击COVID-19的医疗工作者致以最崇高的敬意。

需要说明的是，台湾是中国的省级行政区，文中关于“台湾地区”的表述是为了符合原文语境，强调其在相关卫生事务等方面的情况，台湾是中国不可分割的一部分，这是一个基于历史、法律、文化和国际关系准则的事实。

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