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病例报告：肺炎球菌慢性无菌性脑膜炎后脑脊液中肺炎球菌多糖持续存在：偶然现象还是（自身）炎症余烬。

Case Report: Persistency Pneumococcal Polysaccharide in Cerebrospinal Fluid During a Post Pneumococcal Chronic Aseptic Meningitis: Coincidental or (Auto-)Inflammatory Embers.

作者信息

Ladeveze Manon, Dumont Yann, Boursier G, Batteux Frederic, Mahe Perrine, Bensimon Borrull Aurelie, Sarrabay Guillaume, Bollore Karine, Tuaillon Edouard, Godreuil Sylvain, Jeziorski Eric

机构信息

Département Urgences Post-Urgences, CEREMAIA, CHU de Montpellier, Montpellier, France.

Laboratoire de Bactériologie, CHU de Montpellier, Montpellier, France.

出版信息

Front Pediatr. 2022 Feb 9;10:762457. doi: 10.3389/fped.2022.762457. eCollection 2022.

DOI:10.3389/fped.2022.762457
PMID:35223689
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8864159/
Abstract

We report the case of a 9-months-old boy that has presented a steroid-dependent post-pneumococcal chronic aseptic meningitis was associated with persistence of pneumococcal cell wall components in cerebrospinal fluid during more than 20 months. Suggesting that this antigenic persistence could be involved in post-infectious manifestations through innate immunity response.

摘要

我们报告了一例9个月大的男孩，他患有类固醇依赖型肺炎球菌感染后慢性无菌性脑膜炎，脑脊液中肺炎球菌细胞壁成分持续存在超过20个月。这表明这种抗原持续存在可能通过先天免疫反应参与感染后的表现。

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本文引用的文献

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Cochrane Database Syst Rev. 2015 Sep 12;2015(9):CD004405. doi: 10.1002/14651858.CD004405.pub5.
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Low opsonic activity to the infecting serotype in pediatric patients with invasive pneumococcal disease.侵袭性肺炎球菌病患儿对感染血清型的低调理活性。
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Persistence of pneumolysin in the cerebrospinal fluid of patients with pneumococcal meningitis is associated with mortality.
肺炎链球菌性脑膜炎患者脑脊液中肺炎球菌溶血素的持续存在与死亡率相关。
Clin Infect Dis. 2012 Mar 1;54(5):701-5. doi: 10.1093/cid/cir926. Epub 2012 Jan 11.
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Pathogenesis and pathophysiology of pneumococcal meningitis.肺炎球菌性脑膜炎的发病机制和病理生理学。
Clin Microbiol Rev. 2011 Jul;24(3):557-91. doi: 10.1128/CMR.00008-11.
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Report of two cases of aseptic meningitis with persistence of pneumococcal cell wall components in cerebrospinal fluid after Pneumococcal meningitis.肺炎球菌性脑膜炎后脑脊液中肺炎球菌细胞壁成分持续存在的两例无菌性脑膜炎报告。
J Clin Microbiol. 2006 Nov;44(11):4285-7. doi: 10.1128/JCM.01120-06. Epub 2006 Sep 27.
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Rapid diagnosis of pneumococcal meningitis: implications for treatment and measuring disease burden.肺炎球菌性脑膜炎的快速诊断：对治疗及疾病负担评估的意义
Pediatr Infect Dis J. 2005 Dec;24(12):1093-8. doi: 10.1097/01.inf.0000190030.75892.78.
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J Infect Dis. 1985 Mar;151(3):535-40. doi: 10.1093/infdis/151.3.535.