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脑脊液乳酸水平在脑膜炎诊断中的应用

Diagnostic use of cerebrospinal fluid lactic acid levels in meningitis.

作者信息

Dwivedi C, Reddy C M

出版信息

J Med. 1983;14(5-6):395-403.

PMID:6583298
Abstract

Analysis of cerebrospinal fluid lactic acid levels in 62 patients suspected of having meningitis was performed. Lactic acid was measured enzymatically using lactic acid dehydrogenase with the liberation of NADH. In a control (no meningitis) group, 46 children had a mean cerebrospinal fluid lactic acid level of 14.7 +/- 2.2 mg/dl; 3 with febrile seizure had a mean lactic acid level of 33.5 +/- 0.98 mg/dl. In 9 cases of bacterial meningitis, the mean lactic acid level was 54.8 +/- 16.8 mg/dl. In 3 patients of aseptic meningitis, the mean lactic acid level was 34.5 +/- 1.0 mg/dl. Serial lactate determination was done in three patients and they were well correlated with the clinical response and other cerebrospinal fluid findings. These data suggest that the determination of cerebrospinal fluid lactic acid may be of diagnostic value in differentiating between bacterial and aseptic meningitis.

摘要

对62例疑似脑膜炎患者的脑脊液乳酸水平进行了分析。使用乳酸脱氢酶通过酶法测定乳酸,同时释放出NADH。在对照组(无脑膜炎)中,46名儿童的脑脊液乳酸平均水平为14.7±2.2mg/dl;3名热性惊厥患儿的乳酸平均水平为33.5±0.98mg/dl。9例细菌性脑膜炎患者的乳酸平均水平为54.8±16.8mg/dl。3例无菌性脑膜炎患者的乳酸平均水平为34.5±1.0mg/dl。对3例患者进行了系列乳酸测定,其结果与临床反应及其他脑脊液检查结果密切相关。这些数据表明,脑脊液乳酸测定在鉴别细菌性和无菌性脑膜炎方面可能具有诊断价值。

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