Park Jonghyuk, De Ranjit
School of Life Science, Handong Global University, Pohang 37554, Republic of Korea.
Polymers (Basel). 2025 Aug 19;17(16):2244. doi: 10.3390/polym17162244.
The progress in biopolymers and their composites as advanced materials for wound healing has revolutionized therapeutic approaches for skin regeneration. These materials can effectively integrate their inherent biocompatibility and biodegradability with the enhanced mechanical strength and customizable properties of polymers and functional additives. This review presents a detailed investigation of the design principles, classifications, and biomedical applications of biopolymeric composites, focusing on their capabilities to promote angiogenesis, exhibit antimicrobial activities, and facilitate controlled drug delivery. By overcoming the challenges of conventional wound dressings, such as inadequate exudate management, mechanical fragility, and cytotoxicity, these composites provide dynamic, stimuli-responsive platforms that can adapt to the wound microenvironment. This study further highlights innovative advances in nanoparticle-assisted reinforcement, fiber-based scaffolds, and multi-stimuli responsive smart delivery systems. Finally, the future perspective illustrates how the challenges related to long-term physiological stability, scalable manufacturing, and clinical implementation can be addressed. Overall, this article delivers a comprehensive framework for understanding the transformative impact of biopolymeric composites in next-generation wound care.
生物聚合物及其复合材料作为用于伤口愈合的先进材料所取得的进展，彻底改变了皮肤再生的治疗方法。这些材料能够有效地将其固有的生物相容性和生物降解性与聚合物及功能添加剂增强的机械强度和可定制特性相结合。本综述对生物聚合物复合材料的设计原则、分类和生物医学应用进行了详细研究，重点关注其促进血管生成、展现抗菌活性以及实现可控药物递送的能力。通过克服传统伤口敷料的挑战，如渗出液管理不足、机械脆弱性和细胞毒性，这些复合材料提供了能够适应伤口微环境的动态、刺激响应平台。本研究进一步突出了纳米颗粒辅助增强、基于纤维的支架和多刺激响应智能递送系统方面的创新进展。最后，未来展望阐述了如何应对与长期生理稳定性、可扩展制造和临床实施相关的挑战。总体而言，本文提供了一个全面的框架，以理解生物聚合物复合材料在下一代伤口护理中的变革性影响。
