Key Laboratory of Carbohydrate Science and Engineering, Chongqing Key Laboratory of Inorganic Functional Materials, Chongqing Normal University, Chongqing 401331, China.
Key Laboratory of Carbohydrate Science and Engineering, Chongqing Key Laboratory of Inorganic Functional Materials, Chongqing Normal University, Chongqing 401331, China.
Biomed Pharmacother. 2021 Dec;144:112332. doi: 10.1016/j.biopha.2021.112332. Epub 2021 Oct 19.
Polysaccharides have anti-virus, anti-cancer, anti-oxidation, immune regulation, hypoglycemia and other biological activities. Because of their safety, fewer side effects and other advantages, polysaccharides are considered as ideal raw materials in food and drugs. The biological activity of polysaccharides can be improved by structural modification (such as sulfation, carboxymethylation, phosphorylation, etc.), and even new biological activity can be generated. In this review, the recent advances in the phosphorylation of polysaccharides were reviewed from the perspectives of modification methods, structures, biological activities and structure-activity relationships.
多糖具有抗病毒、抗癌、抗氧化、免疫调节、降血糖等生物活性。由于其安全性、副作用少等优点，多糖被认为是食品和药物中理想的原料。多糖的生物活性可以通过结构修饰（如硫酸化、羧甲基化、磷酸化等）来提高，甚至可以产生新的生物活性。本文从修饰方法、结构、生物活性和构效关系等方面综述了近年来多糖磷酸化的研究进展。
