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髓外骨整合——一种用于截肢者的经皮骨整合假体的新型设计

Extramedullary Osseointegration-A Novel Design of Percutaneous Osseointegration Prosthesis for Amputees.

作者信息

Sun Yingying, Xu Jinying, Lv Shuang, Xu Ziran, Li Lisha, Li Yan, Li Yulin

机构信息

The Key Laboratory of Pathobiology, Ministry of Education, College of Basic Medical Sciences, Jilin University, Changchun, China.

Department of Stomatology, the First Hospital of Jilin University, Changchun, China.

出版信息

Front Bioeng Biotechnol. 2022 Feb 10;10:811128. doi: 10.3389/fbioe.2022.811128. eCollection 2022.

DOI:10.3389/fbioe.2022.811128
PMID:35223785
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8867013/
Abstract

The percutaneous osseointegrated (OI) prostheses have greatly improved the overall quality of life for amputees. However, the long-term maintenance of the OI prostheses is still challenging. A major problem is bone resorption around the bone-implant-skin interface, which might cause implant loosening or osteomyelitis. Another problem is the breakage of connecting components between the intramedullary implant and external prosthesis due to excessive stress. We designed a novel osseointegration implant by changing the bone-implant contact from the inner cortex to the outer surface of cortical bone. In the current study, we compared the extramedullary cap-shaped implants with the intramedullary screw-type implants in rabbits. Osteointegration was confirmed at the interface of bone to implant contact (BIC) in both implant types. The external implant induced intramedullary bone regeneration in the medullary canal and increased the cortical bone density at the end of the stump. This study provides a new perspective on the design of osseointegration implants which might prevent the currently reported complications of the intramedullary OI systems.

摘要

经皮骨整合（OI）假体极大地改善了截肢者的整体生活质量。然而，OI假体的长期维护仍然具有挑战性。一个主要问题是骨-植入物-皮肤界面周围的骨吸收，这可能导致植入物松动或骨髓炎。另一个问题是由于过度应力导致髓内植入物与外部假体之间的连接部件断裂。我们通过将骨-植入物接触从内皮质改变为皮质骨外表面，设计了一种新型骨整合植入物。在本研究中，我们在兔子身上比较了髓外帽状植入物和髓内螺旋型植入物。两种植入物类型在骨与植入物接触（BIC）界面均证实有骨整合。外部植入物诱导了髓腔内的髓内骨再生，并增加了残端末端的皮质骨密度。本研究为骨整合植入物的设计提供了新的视角，这可能预防目前报道的髓内OI系统并发症。

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