Lin Chu-Sheng, Lee Wei-Ju, Lin Shih-Yi, Lin Hui-Ping, Chen Ran-Chou, Lin Chi-Hung, Chen Liang-Kung
Department of Family Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.
Center for Geriatrics and Gerontology, Taichung Veterans General Hospital, Taichung, Taiwan.
Front Med (Lausanne). 2022 Feb 11;8:698728. doi: 10.3389/fmed.2021.698728. eCollection 2021.
Metabolic syndrome has been shown to be a risk for new onset of cardiovascular disease (CVD) and type 2 diabetes. The subclasses of metabolic syndrome and any associated adverse health outcomes remain obscure. This study aimed to explore potential subtypes of metabolic syndrome, their associations with incidental diabetes, and any Major Adverse Cardiovascular Events (MACE).
Data for the retrospective cohort study were extracted from the New Taipei City Elderly Health Examination Database in the years 2014 and 2016. Demographic data, status of metabolic syndrome, its components, and latent class analysis (LCA) were analyzed. All participants were aged 65 years and older, with those having a prior history of CVD, cerebrovascular disease, diabetes mellitus (DM), and currently taking medications for hypertension, diabetes, and dyslipidemia were excluded.
A total of 4,537 senior citizens were enrolled, with 2,207 (48.6%) of them identified as men. The prevalence of both metabolic syndrome and central obesity was increased with age. A 4-latent class model was fitted for participants diagnosed with metabolic syndrome. The central obesity (ABD)+ hyperglycemia (GLU)+ reduced HDL-C (HDL)+ high Blood Pressure (BP) group displayed the highest hazard ratio (HR) for predicting the new onset of diabetes, while the ABD+HDL+BP group showed a high risk for both CVD and MACE when compared after 2 years of follow-up.
This epidemiological analysis demonstrated that the risks of developing new-onset diabetes, CVD, and MACE varied among the different subtypes of metabolic syndrome.
代谢综合征已被证明是新发心血管疾病（CVD）和2型糖尿病的危险因素。代谢综合征的亚类及其任何相关的不良健康后果仍不明确。本研究旨在探索代谢综合征的潜在亚型、它们与偶发性糖尿病的关联以及任何主要不良心血管事件（MACE）。
回顾性队列研究的数据取自2014年和2016年新北市老年健康检查数据库。分析了人口统计学数据、代谢综合征状况、其组成成分以及潜在类别分析（LCA）。所有参与者年龄均在65岁及以上，排除有CVD、脑血管疾病、糖尿病（DM）既往史以及目前正在服用高血压、糖尿病和血脂异常药物的患者。
共纳入4537名老年人，其中2207名（48.6%）为男性。代谢综合征和中心性肥胖的患病率均随年龄增加。对诊断为代谢综合征的参与者拟合了一个4潜在类别模型。中心性肥胖（ABD）+高血糖（GLU）+高密度脂蛋白胆固醇降低（HDL）+高血压（BP）组在预测糖尿病新发方面显示出最高风险比（HR），而在随访2年后比较时，ABD+HDL+BP组在CVD和MACE方面均显示出高风险。
这项流行病学分析表明，代谢综合征不同亚型在发生新发糖尿病、CVD和MACE的风险方面存在差异。
