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经皮低功率激光椎间盘切除术与低温等离子体射频消融术治疗神经根型颈椎病的临床与影像学比较:一项前瞻性、多中心、队列研究

Clinical and Radiological Comparisons of Percutaneous Low-Power Laser Discectomy and Low-Temperature Plasma Radiofrequency Ablation for Cervical Radiculopathy: A Prospective, Multicenter, Cohort Study.

作者信息

Lan Xueqin, Wang Ziyang, Huang Yuzhao, Ni Yuncheng, He Yunwu, Wang Xiaofeng, Wu Chunsheng, Hu Rong, Han Rui, Guo Gangwen, Li Zhenxing, Zhang Xuan, Zhang Jianping, Liao Qin, Huang Dong, Zhou Haocheng

机构信息

Department of Pain, Institute of Pain Medicine, The Third Xiangya Hospital, Central South University, Changsha, China.

Department of Anesthesiology, The Affiliated Changsha Central Hospital, University of South China, Changsha, China.

出版信息

Front Surg. 2022 Feb 9;8:779480. doi: 10.3389/fsurg.2021.779480. eCollection 2021.

Abstract

BACKGROUND

Minimally invasive techniques, such as percutaneous low-power laser discectomy (PLLD) and low-temperature plasma radiofrequency ablation (coblation) can be applied to treat degenerative cervical radiculopathy. However, less evidence supports the superiority of distinct minimally-invasive therapy. Our study aimed to evaluate the clinical and radiological characteristics of the PLLD and coblation for cervical radiculopathy.

METHODS

This was a prospective, multicenter, cohort study (ChiCTR-ONC-17010356). The modified Macnab criteria was performed to assess the clinical improvement pre- and post-surgery. To evaluate the radiological effect, the Pfirrmann grading system and disk herniation index were applied with MRI.

RESULTS

In this study, 28 patients were enrolled in the coblation group and 30 patients in the PLLD group. The mean good-excellent rate at 3-month follow-up was 82.1% for PLLD group, and 66.7% for coblation group, respectively ( = 0.179). The PLLD group achieved higher good-excellent rate 6 and 12 months after discharge (92.9 vs. 70.0%, = 0.026). Radiological data revealed that PLLD but not coblation treatment achieved significant reduction of disk herniation index ( < 0.0001). Coblation treatment did not change the Pfirrmann grades of cervical radiculopathy patients ( = 18), and 7 out of 17 (41.2%) patients achieved improvement after PLLD therapy. None obvious adverse event was observed in this study.

CONCLUSION

Both PLLD and coblation are effective and safe option for patients with cervical radiculopathy. Better long-term clinical outcomes may be potentially associated with the improvement of disk degeneration after PLLD treatment.

摘要

背景

微创技术,如经皮低功率激光椎间盘切除术(PLLD)和低温等离子体射频消融术(消融)可用于治疗退行性颈椎神经根病。然而,支持不同微创治疗优越性的证据较少。我们的研究旨在评估PLLD和消融治疗颈椎神经根病的临床和影像学特征。

方法

这是一项前瞻性、多中心队列研究(ChiCTR-ONC-17010356)。采用改良Macnab标准评估手术前后的临床改善情况。为评估影像学效果,应用Pfirrmann分级系统和椎间盘突出指数进行MRI检查。

结果

本研究中,消融组纳入28例患者,PLLD组纳入30例患者。PLLD组3个月随访时的平均优良率为82.1%,消融组为66.7%(P = 0.179)。PLLD组出院后6个月和12个月的优良率更高(92.9%对70.0%,P = 0.026)。影像学数据显示,PLLD治疗可显著降低椎间盘突出指数(P < 0.0001),而消融治疗则无此效果。消融治疗未改变颈椎神经根病患者的Pfirrmann分级(P = 18),17例患者中有7例(41.2%)在PLLD治疗后病情改善。本研究未观察到明显不良事件。

结论

PLLD和消融对于颈椎神经根病患者都是有效且安全的选择。更好的长期临床结果可能与PLLD治疗后椎间盘退变的改善有关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b7f/8863912/768a8f9ba0c1/fsurg-08-779480-g0001.jpg

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