Zeng Yinuo, Acord Molly, Kaovasia Tarana Parvez, Miao Peng, Sun Junfeng, Senarathna Janaka, Theodore Nicholas, Thakor Nitish, Manbachi Amir
Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA.
Department of Biomedical Engineering, Shanghai Jiaotong University, Shanghai, China.
Proc Des Med Devices Conf. 2021 Apr;2021. doi: 10.1115/dmd2021-1038. Epub 2021 May 11.
Transcranial focused ultrasound stimulation is a neuromodulation technique that is capable of exciting or suppressing the neural network. Such neuro-modulatory effects enable the treatment of brain diseases non-invasively, such as treating stroke. The neuro-modulatory effect on cerebral hemodynamics has been monitored using laser speckle contrast imaging in animal studies. However, the bulky size and stationary nature of the imaging system constrains the application of this imaging technique on research that requires the animal to have different body positions or to be awake. We present the design of a system that combines a miniature microscope for laser speckle contrast imaging and transcranial focused ultrasound stimulation, as well as, test its capability to monitor cerebral hemodynamics during stimulation and compare the result with a benchtop imaging system.
经颅聚焦超声刺激是一种能够激发或抑制神经网络的神经调节技术。这种神经调节作用能够以非侵入性方式治疗脑部疾病，比如治疗中风。在动物研究中，已使用激光散斑对比成像监测其对脑血流动力学的神经调节作用。然而，成像系统体积庞大且固定不动，这限制了该成像技术在需要动物处于不同体位或清醒状态的研究中的应用。我们展示了一种将用于激光散斑对比成像的微型显微镜与经颅聚焦超声刺激相结合的系统设计，并测试其在刺激过程中监测脑血流动力学的能力，同时将结果与台式成像系统进行比较。
