阳极直流电刺激对激光散斑对比成像下皮质血流动力学反应的影响

Hu Shuo, Zheng Tao, Dong Yanchao, Du Juan, Liu Lanxiang

Institute of Electrical Engineering, Yanshan University, Qinhuangdao, China.

Department of Magnetic Resonance Imaging, Qinhuangdao Municipal No. 1 Hospital, Qinhuangdao, China.

Front Neurosci. 2018 Jul 26;12:503. doi: 10.3389/fnins.2018.00503. eCollection 2018.

Transcranial direct-current stimulation (DCS) offers a method for noninvasive neuromodulation usable in basic and clinical human neuroscience. Laser-speckle contrast imaging (LSCI), a powerful, low-cost method for obtaining images of dynamic systems, can detect regional blood-flow distributions with high spatial and temporal resolutions. Here, we used LSCI for measuring DCS-induced cerebral blood flow in real-time. Results showed that the change-rate of cerebral blood flow could reach approximately 10.1 ± 5.1% by DCS, indicating that DCS can increase cerebral blood flow and alter cortical hemodynamic responses. Thus, DCS shows potential for the clinical treatment and rehabilitation of ischemic strokes.

经颅直流电刺激（DCS）提供了一种可用于基础和临床人类神经科学的非侵入性神经调节方法。激光散斑对比成像（LSCI）是一种用于获取动态系统图像的强大且低成本的方法，它能够以高空间和时间分辨率检测局部血流分布。在此，我们使用LSCI实时测量DCS诱导的脑血流量。结果显示，经DCS刺激后，脑血流量的变化率可达约10.1±5.1%，这表明DCS能够增加脑血流量并改变皮质血流动力学反应。因此，DCS在缺血性中风的临床治疗和康复方面显示出潜力。