Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, South Carolina.
Department of Surgery, Division of Transplant Surgery, Medical University of South Carolina, Charleston, South Carolina.
Am J Transplant. 2022 May;22(5):1293-1298. doi: 10.1111/ajt.17012. Epub 2022 Mar 10.
Patients undergoing organ transplantation transition from one life-altering issue (organ dysfunction) to a lifelong commitment-immunosuppression. Regimens of immunosuppressive agents (ISAs) come with significant side effects and comorbidities. Recently, the use of nanoparticles (NPs) as a solution to the problems associated with the long-term and systemic use of ISAs in transplantation has emerged. This minireview describes the role of NPs in organ transplantation and discusses obstacles to clinical implementation and pathways to clinical translation.
接受器官移植的患者从一个改变生活的问题（器官功能障碍）转变为终身承诺-免疫抑制。免疫抑制剂（ISAs）的方案伴随着显著的副作用和合并症。最近，纳米颗粒（NPs）作为一种解决方案，用于解决与长期和系统使用 ISAs 在移植中相关的问题已经出现。这篇小型综述描述了 NPs 在器官移植中的作用，并讨论了临床实施的障碍和临床转化的途径。
