荨麻在乳腺癌中的抗癌作用。

Anticancer Effects of Urtica Dioica in Breast Cancer.

机构信息

Plastic Reconstructive and Aesthetic Surgery, Health Science University, Bagcilar Education and Training Hospital, Istanbul, Turkey.

Department of Histology and Embryology, Faculty of Medicine, Cumhuriyet University, Sivas, Turkey.

出版信息

Asian Pac J Cancer Prev. 2022 Feb 1;23(2):673-681. doi: 10.31557/APJCP.2022.23.2.673.

OBJECTIVE

The goal of this study is to look into the antiproliferative capabilities of Urtica Dioica (UD) on breast cancer.

METHODS

The cytotoxicity of UD extracts against breast cancer cell lines was investigated. Flow cytometry analyses were used to investigate in vitro apoptosis of breast cancer cells using Annexin V labeling. In vivo tests also performed.

RESULTS

UD showed cytotoxicity to three cancer cell lines. The number of Annexin-positive cells was higher in UD-treated cell lines than in untreated control cells. When compared to the untreated control group, the rats treated with UD had greater expressions of caspase 3, p53 protein, and TUNEL positive cells. When compared to the control group, Ki-67 expression was reduced in the treatment groups. In vivo tests revealed that, when compared to untreated rats, the mean tumor volume inhibition ratio in the UD group was 38 percent.

CONCLUSION

These findings suggest that Urtica Dioica may have antitumoral properties in the treatment of breast cancer.

目的

本研究旨在探讨荨麻（UD）对乳腺癌的抗增殖作用。

方法

研究了 UD 提取物对乳腺癌细胞系的细胞毒性。使用 Annexin V 标记通过流式细胞术分析研究乳腺癌细胞的体外细胞凋亡。还进行了体内试验。

结果

UD 对三种癌细胞系均表现出细胞毒性。与未处理的对照细胞相比，UD 处理的细胞系中 Annexin 阳性细胞的数量更多。与未处理的对照组相比，用 UD 处理的大鼠中 caspase 3、p53 蛋白和 TUNEL 阳性细胞的表达更高。与对照组相比，Ki-67 表达在治疗组中降低。体内试验表明，与未处理的大鼠相比，UD 组的平均肿瘤体积抑制率为 38%。