Department of Environmental, Biological, and Pharmaceutical Sciences and Technologies, University of Campania "Luigi Vanvitelli", 81100 Caserta, Italy.
Molecules. 2019 Jul 29;24(15):2753. doi: 10.3390/molecules24152753.
A large range of chronic and degenerative diseases can be prevented through the use of food products and food bioactives. This study reports the health benefits and biological activities of the () edible plant, with particular focus on its cancer chemopreventive potential. Numerous studies have attempted to investigate the most efficient anti-cancer therapy with few side effects and high toxicity on cancer cells to overcome the chemoresistance of cancer cells and the adverse effects of current therapies. In this regard, natural products from edible plants have been assessed as sources of anti-cancer agents. In this article, we review current knowledge from studies that have examined the cytotoxic, anti-tumor and anti-metastatic effects of plant on several human cancers. Special attention has been dedicated to the treatment of breast cancer, the most prevalent cancer among women and one of the main causes of death worldwide. The anti-proliferative and apoptotic effects of have been demonstrated on different human cancers, investigating the properties of at cellular and molecular levels. The potent cytotoxicity and anti-cancer activity of the extracts are due to its bioactive natural products content, including polyphenols which reportedly possess anti-oxidant, anti-mutagenic and anti-proliferative properties. The efficacy of this edible plant to prevent or mitigate human cancers has been demonstrated in laboratory conditions as well as in experimental animal models, paving the way to the development of nutraceuticals for new anti-cancer therapies.
大量的慢性和退行性疾病可以通过食用产品和食品生物活性物质来预防。本研究报告了 () 可食用植物的健康益处和生物活性，特别关注其癌症化学预防潜力。许多研究试图寻找最有效的抗癌治疗方法，具有较少的副作用和对癌细胞的高毒性，以克服癌细胞的化疗耐药性和当前治疗方法的不良反应。在这方面，来自食用植物的天然产物已被评估为抗癌药物的来源。在本文中，我们综述了研究中检查植物对几种人类癌症的细胞毒性、抗肿瘤和抗转移作用的现有知识。特别关注乳腺癌的治疗，乳腺癌是女性中最常见的癌症之一，也是全球死亡的主要原因之一。植物对不同人类癌症的抗增殖和促凋亡作用已经在细胞和分子水平上进行了研究。的提取物具有很强的细胞毒性和抗癌活性，这是由于其生物活性天然产物含量高，包括多酚，据报道多酚具有抗氧化、抗突变和抗增殖特性。这种可食用植物在实验室条件下以及实验动物模型中预防或减轻人类癌症的功效已经得到证实，为开发新的抗癌疗法的营养保健品铺平了道路。
