Helmkamp G M
J Bioenerg Biomembr. 1986 Apr;18(2):71-91. doi: 10.1007/BF00743477.
Phospholipid transfer proteins are generally localized in the cytosolic fraction of cells and are capable of catalyzing the flux of phospholipid molecules among membranes. Artificial membranes also participate in protein-catalyzed phospholipid movements. In this review the major phospholipid transfer proteins are discussed with respect to their phospholipid substrate specificity and the contributions of membrane physical properties to this process. The phenomenon of net transfer of phospholipids is described. The use of various kinetic approaches to the study of these catalysts is reviewed. A detailed consideration of the distinct phospholipid binding and membrane interaction domains of one phospholipid transfer protein is presented. Finally, some recent applications of phospholipid transfer proteins to the examination of membrane structure and function and further directions for the continued research activity with this class of proteins are summarized.
磷脂转移蛋白通常定位于细胞的胞质部分，能够催化磷脂分子在膜之间的流动。人工膜也参与蛋白质催化的磷脂运动。在这篇综述中，主要的磷脂转移蛋白将根据其磷脂底物特异性以及膜物理性质对这一过程的贡献进行讨论。文中描述了磷脂净转移现象。综述了研究这些催化剂的各种动力学方法。对一种磷脂转移蛋白独特的磷脂结合和膜相互作用结构域进行了详细探讨。最后，总结了磷脂转移蛋白在膜结构和功能研究中的一些最新应用以及这类蛋白质后续研究活动的进一步方向。
