Liapkov B G, Gapparov M M
Vopr Med Khim. 1980 Sep-Oct;26(5):579-87.
A review is presented on the transport of phospholipids between subcellular membranes and participation of specific intracellular lipoproteins in this process. Formation of the protein-lipid complex is specific in relation to both protein and phospholipid. The rate of turnover of various phospholipids is dissimilar in membranes; the most intensive transport of phospholipids occurs across the outer surface of the membranes. The most important properties of the phospholipid transferases are discussed and their specificity in the transport of various phospholipids is considered. Role of these proteins in differentiation of phospholipids in membranes of tiumoral cells, significance for simulation of the phospholipid composition of biomembranes in their reconstruction are also discussed.
本文综述了磷脂在亚细胞膜之间的转运以及特定细胞内脂蛋白在此过程中的参与情况。蛋白质 - 脂质复合物的形成在蛋白质和磷脂方面都具有特异性。不同磷脂在膜中的周转速率不同;磷脂的最活跃转运发生在膜的外表面。讨论了磷脂转移酶的最重要特性,并考虑了它们在各种磷脂转运中的特异性。还讨论了这些蛋白质在肿瘤细胞膜磷脂分化中的作用以及在生物膜重建中模拟其磷脂组成的意义。