Gonzalez J G, Marcus M D, Cruz D J
J Am Acad Dermatol. 1986 Jul;15(1):87-92. doi: 10.1016/s0190-9622(86)70148-5.
A case of drug-induced lichenoid dermatitis with an unusual epidermotropic multinucleated giant cell inflammatory response is reported. The patient is a 52-year-old white woman who is steroid-dependent because of long-standing systemic lupus erythematosus. At the time of presentation of her generalized papulosquamous pruritic eruption, she was taking oral antihypertensive medications (methyldopa and chlorothiazide). After discontinuation of these medications and local treatment with topical corticosteroids, the skin eruption dramatically improved. Microscopically, the skin lesions had a lichenoid inflammatory pattern, with multiple cytoid bodies, multinucleated giant cells, and a mixed chronic inflammatory infiltrate that included lymphocytes, histiocytes, and eosinophils.
报告了一例药物性苔藓样皮炎，伴有不寻常的亲表皮多核巨细胞炎症反应。患者为一名52岁的白人女性，因长期系统性红斑狼疮而依赖类固醇。在出现全身性丘疹鳞屑性瘙痒性皮疹时，她正在服用口服抗高血压药物（甲基多巴和氯噻嗪）。停用这些药物并局部使用外用皮质类固醇治疗后，皮疹明显改善。显微镜下，皮肤病变呈苔藓样炎症模式，有多个细胞样体、多核巨细胞以及包括淋巴细胞、组织细胞和嗜酸性粒细胞在内的混合性慢性炎症浸润。
